Regenerative Medicine and the Biliary Tree.
Regenerative Medicine and the Biliary Tree.
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DOI：
10.1055/s-0036-1597818
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发表时间：
2017-02
影响因子：
4.2
通讯作者：
Huebert RC
中科院分区：
文献类型：
--
作者：
De Assuncao TM;Jalan-Sakrikar N;Huebert RC
尽管进行了数十年的基础研究，胆道疾病仍然普遍存在，发病率很高，而且非常难以治疗。然而，我们极大地增加了对胆道发育生物学、胆管细胞病理生理学以及胆道再生和修复的内源性机制的理解。所有这些复杂且快速发展的知识与再生医学领域新技术进步的爆发同时发生。诱导多能干细胞和类器官培养等新突破越来越多地应用于胆道系统，现在针对胆管病的新再生疗法的面世只是时间问题。在这篇综述中，我们将整合有关胆道发育、再生和修复的知识，并将这些概念进步与技术突破联系起来，共同推动胆道再生医学全球新领域的出现。
Despite decades of basic research, biliary diseases remain prevalent, highly morbid, and notoriously difficult to treat. We have, however, dramatically increased our understanding of biliary developmental biology, cholangiocyte pathophysiology, and the endogenous mechanisms of biliary regeneration and repair. All of this complex and rapidly evolving knowledge coincides with an explosion of new technological advances in the area of regenerative medicine. New breakthroughs such as induced pluripotent stem cells and organoid culture are increasingly being applied to the biliary system and now it is only a matter of time until new regenerative therapeutics for the cholangiopathies are unveiled. In this review, we will integrate what is known about biliary development, regeneration, and repair and we will link these conceptual advances to the technological breakthroughs that are collectively driving the emergence of a new global field in biliary regenerative medicine.