Phenelzine and Amitriptyline: Effects on Symptoms of Neurotic Depression
Phenelzine and Amitriptyline: Effects on Symptoms of Neurotic Depression
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苯乙肼和阿米替林：对神经质抑郁症症状的影响
DOI：
10.1192/bjp.140.5.475
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发表时间：
1982
影响因子：
10.5
通讯作者：
R. R. Parker
中科院分区：
文献类型：
--
作者：
P. Rowan;E. Paykel;R. R. Parker
在患有抑郁症或混合焦虑和抑郁症的门诊患者中进行了苯乙肼、阿米替林和安慰剂的双盲对照试验。治疗六周后，两种活性药物明显上级安慰剂，疗效相似;治疗效果在两周后开始显现。对症状评级的比较表明，这两种药物都是真正的抗抑郁药，对抑郁情绪和思想内容的评级产生了最大的影响。有额外的弱差异，苯乙肼产生更多的改善焦虑等级，而阿米替林给予更大的影响，对抑郁障碍的工作和兴趣和运动障碍。分析显示，临床亚组对任一药物的反应优先的证据很少。研究结果表明，单胺氧化酶抑制剂和三环类抗抑郁药的临床效果比想象的更接近，对于这些通常被认为对抗抑郁药物治疗反应不佳的患者来说，这两种药物都可能是一种有用的治疗方法。
Summary A double-blind controlled trial of phenelzine, amitriptyline and placebo was carried out in out-patients suffering from depression or mixed anxiety and depression. After six weeks treatment both active drugs were clearly superior to placebo and of similar efficacy; therapeutic effects started to appear at two weeks. Comparisons on symptom ratings showed that both drugs acted as true antidepressants, producing their greatest effects on ratings of depressive mood and thought content. There were additional weak differences, phenelzine producing more improvement on anxiety ratings, while amitriptyline gave greater effects on depressive impairment of work and interests and anergia. Analyses showed little evidence of clinical subgroups responding preferentially to either drug. The findings indicate that MAO inhibitors and tricyclic antidepressants have more closely similar clinical effects than has been thought and that either may be a useful treatment for these patients who are often considered to respond poorly to antidepressant drug treatment.