Fibronectin: a brief overview of its structure, function, and physiology.
Fibronectin: a brief overview of its structure, function, and physiology.
复制标题
纤连蛋白：其结构、功能和生理学的简要概述。
DOI：
10.1093/clinids/9.supplement_4.s317
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Proctor,RA
中科院分区：
文献类型：
--
作者：
Proctor,RA
纤维连接蛋白是一种大的糖蛋白，由三种类型的重复、同源的多肽序列组成。几个同源的块形成在两个几乎相同的亚单位臂上以线性阵列组织的功能结构域。特定的结构域允许纤维连接蛋白促进细胞与细胞之间的黏附、细胞与基底膜的黏附、凝块的稳定、胚胎发生、神经再生、成纤维细胞迁移、巨噬细胞功能以及病原体(病毒、真菌、细菌和原生动物)与哺乳动物细胞和细胞外基质的结合。因此，这种复杂而多功能的蛋白从感染开始到伤口愈合的最后阶段都参与了感染的发病过程。
Fibronectin is a large glycoprotein that is composed of blocks of three types of repeating, homologous peptide sequences. Several of the homologous blocks form functional domains that are organized in a linear array on two nearly identical subunit arms. Specific domains allow fibronectin to promote cell-to-cell adhesion, cell-to-basement-membrane attachment, clot stabilization, embryogenesis, nerve regeneration, fibroblast migration, macrophage function, and pathogen (virus, fungus, bacteria, and protozoa) binding to mammalian cells and extracellular matrix. Thus, this complex and multifunctional protein is involvedin the pathogenesis of infections from the initiation of the infection through the final stages of wound healing.