Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats
Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats
复制标题
DOI：
10.1016/j.fct.2006.10.019
复制
发表时间：
2007-05-01
影响因子：
4.3
通讯作者：
Chawan, C. B.
中科院分区：
文献类型：
--
作者：
Boateng, J.;Verghese, M.;Chawan, C. B.
植物化学物质有助于水果鲜艳的颜色，有人认为，水果颜色越深，抗氧化或抗癌性能越高。本研究探讨了蓝莓（BLU）、黑莓（BLK）、李子（PLM）、芒果（MAN）、石榴汁（POJ）、西瓜汁（WMJ）和蔓越莓汁（CBJ）对偶氮氧甲烷（AOM）诱导的雄性Fisher 344大鼠异常隐窝病灶（ACF）的可能影响。48只雄性Fisher 344大鼠随机分为8组（n = 6）。各组以AIN-93G为对照(C)，水果组以AIN-93G + 5%水果喂养，果汁组以20%果汁代替水喂养。7、8周龄大鼠皮下注射AOM，剂量为16 mg/kg体重。17周龄时，用CO2窒息法杀死大鼠。CON、BLU、BLK、PLM、MNG、POJ、WMJ、CBJ各组大鼠总ACF数（平均+/- SEM）分别为171.67 +/- 5.6、11.33 +/- 2.85、24.0 +/- 0.58、33.67 +/- 0.89、28.67 +/- 1.33、15.67 +/- 1.86、24.33 +/- 3.92和39.0 +/- 15.31。水果和果汁组大鼠肝脏总谷胱甘肽- s转移酶（GST）活性（mu mol/mg）均显著高于对照组（P < 0.05）。结果表明，在水果和果汁中，BLU和POJ对aom诱导的ACF形成有显著（P < 0.05）的减少作用。(c) 2006年Elsevier Ltd出版
Phytochemicals contribute to the vibrant colors of fruits and it is suggested that the darker the fruit the higher the antioxidative or anticarcinogenic properties. In this study we investigated the possible effects of blueberries (BLU), blackberries (BLK), plums (PLM), mangoes (MAN), pomegranate juice (POJ), watermelon juice (WMJ) and cranberry juice (CBJ) on azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats.Forty-eight male Fisher 344 rats were randomly assigned to eight groups (n = 6). The groups were fed AIN-93G as a control (C) diet, the rats fed fruits received AIN-93G + 5% fruits and the groups that were given fruits juices received 20% fruit juice instead of water. The rats received subcutaneous injections of AOM at 16 mg/kg body weight at seventh and eighth weeks of age. At 17th week of age, the rats were killed by CO2 asphyxiation.Total ACF numbers (mean +/- SEM) in the rats fed CON, BLU, BLK, PLM, MNG, POJ, WMJ and CBJ were 171.67 +/- 5.6, 11.33 +/- 2.85, 24.0 +/- 0.58, 33.67 +/- 0.89, 28.67 +/- 1.33, 15.67 +/- 1.86, 24.33 +/- 3.92 and 39.0 +/- 15.31. Total glutathione-S-transferase (GST) activity (mu mol/mg) in the liver of the rats fed fruits (except BLK) and fruit juices were significantly (P < 0.05) higher in the rats fed fruits and fruit juices compared with the control.Our findings suggest that among the fruits and fruit juices, BLU and POJ contributed to significant (P < 0.05) reductions in the formation of AOM-induced ACF. (c) 2006 Published by Elsevier Ltd.