Brain metabolism in minimal hepatic encephalopathy assessed by 3.0-Tesla magnetic resonance spectroscopy
Brain metabolism in minimal hepatic encephalopathy assessed by 3.0-Tesla magnetic resonance spectroscopy
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DOI：
10.1111/hepr.12519
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发表时间：
2016-04-01
影响因子：
4.2
通讯作者：
Takikawa, Yasuhiro
中科院分区：
文献类型：
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作者：
Kooka, Yohei;Sawara, Kei;Takikawa, Yasuhiro
目的应用3.0Tesla(T)H-1质子磁共振波谱(MRS)检测21例LC患者，其中7例为轻度肝性脑病(MHE)患者。结果两组患者在LC严重程度、血氨、血或肝酶水平方面无明显差异。MHE组大鼠脑组织谷氨酰胺水平显著高于非MHE组，而脑肌醇水平显著低于非MHE组。这表明MHE患者已经表现出与临床肝性脑病时相似的脑代谢紊乱。结论MRS对这种现象的定量分析有助于MHE的早期和客观诊断。
AimTo examine whether the brain exhibits metabolic disorder prior to overt hepatic encephalopathy in patients with liver cirrhosis (LC), the intracerebral glutamine and myo-inositol levels were determined using 3.0-Tesla (T)H-1 (proton) magnetic resonance spectroscopy (MRS).MethodsWe tested 21 LC patients, including seven patients with minimal hepatic encephalopathy (MHE).ResultsNo significant differences were noted between the two patient groups in terms of the severity of LC, levels of blood ammonia or levels of blood or liver enzymes. In the MHE group, the levels of brain glutamine were significantly higher than those in the non-MHE group, whereas the levels of brain myo-inositol were significantly lower. This demonstrated that MHE patients were already exhibiting metabolic disorder in the brain, similar to those observed during overt hepatic encephalopathy.ConclusionA quantitative analysis of this phenomenon using MRS may contribute to an early and objective diagnosis of MHE.