Malignant mullerian mixed tumor of the ovary associated with yolk sac tumor, neuroepithelial and trophoblastic differentiation (teratoid carcinosarcoma)
Malignant mullerian mixed tumor of the ovary associated with yolk sac tumor, neuroepithelial and trophoblastic differentiation (teratoid carcinosarcoma)
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DOI：
10.1097/pgp.0b013e31817b06c7
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发表时间：
2008-10-01
影响因子：
2.4
通讯作者：
Nogales, Francisco F.
中科院分区：
文献类型：
--
作者：
Garcia-Galvis, Olga F.;Cabrera-Ozoria, Claudia;Nogales, Francisco F.
本文报告一例69岁卵巢癌肉瘤的独特的IV期复合性肉瘤，该肉瘤具有混合的苗勒氏上皮和间充质恶性成分，也有其他恶性分化，如神经外胚层(小细胞、神经内分泌、神经胶质细胞、神经元和黑素细胞)和内胚层(卵黄囊肿瘤)组织和滋养层细胞。由于它的表型由胚胎学上来自3个生殖层的成分组成，因此提出了将其与源于生殖细胞的畸胎瘤相鉴别的问题，该畸胎瘤与生殖细胞具有三层型分化。它与畸胎瘤不同，因为它与躯体肿瘤共存，并可能起源于躯体肿瘤，即典型的子宫内膜样腺癌。所有出现在肿瘤中的肿瘤组织模式本身都是恶性的，没有明显的成熟梯度或器官样结构的存在。
This paper reports a unique stage IV complex ovarian carcinosarcoma in a 69-year patient that had malignant mixed mullerian epithelial and mesenchymal components and also other malignant differentiation such as neuroectodermal (small cell, neuroendocrine, neuroglial, neuronal, and melanocytic) and endodermal (yolk sac tumor) tissues and trophoblastic cells. As its phenotype comprised elements derived embryologically from the 3 germ layers, it posed the problem of differentiating it from a teratoma originated from germ cells, with which it shared a trilaminar type differentiation. It was different from a teratoma as it coexisted with, and possibly originated from, a somatic tumor, namely a characteristic endometrioid adenocarcinoma. All neoplastic tissue patterns present in the neoplasm were malignant per se without an apparent gradient of maturation or presence of organoid structures.