Molecular drivers of metastatic castrate-resistant prostate cancer: New roads to resistance.
Molecular drivers of metastatic castrate-resistant prostate cancer: New roads to resistance.
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DOI：
10.1080/15384047.2018.1449618
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发表时间：
2018
影响因子：
3.6
通讯作者：
Figg WD
中科院分区：
文献类型：
--
作者：
Huang PA;Price DK;Figg WD
Numerous growth-inducing signaling pathways have been implicated in the development of metastatic castrate-resistant prostate cancer, but their cross-talk with androgen receptor functions remains poorly understood. A recent study published in Science Signaling by Chen et al. has identified a novel androgen-mediated signaling axis driven by loss of SPDEF and gain of TGFBI to facilitate metastasis, which may explain the acquisition of resistance to androgen deprivation therapy. These findings suggest that therapeutic inhibition of androgen signaling may inadvertently promote castrate resistance by inhibiting tumor suppressive functions of the androgen receptor.
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