Starch-based nanocapsules fabricated through layer-by-layer assembly for oral delivery of protein to lower gastrointestinal tract
Starch-based nanocapsules fabricated through layer-by-layer assembly for oral delivery of protein to lower gastrointestinal tract
复制标题
通过逐层组装制备的淀粉基纳米胶囊用于将蛋白质口服输送至下胃肠道
DOI：
10.1016/j.carbpol.2017.04.090
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发表时间：
2017-09-01
影响因子：
11.2
通讯作者：
Chen, Ling
中科院分区：
文献类型：
--
作者：
Zhang, Yiping;Chi, Chengdeng;Chen, Ling
以阴离子羧甲基淀粉（CMS）和阳离子季铵淀粉（QAS）为原料，通过静电层层交替沉积法在BSA胶体颗粒上制备纳米胶囊。通过调节CMS的取代度（DS）和重均相对分子质量（M-w），得到了理想的淀粉基胶体纳米胶囊。具有较低DS或Mw的CMS制备的纳米胶囊具有更致密和稳定的核壳结构，有利于BSA从上胃肠道（GIT）到结肠的递送。其中，由较低DS和M-w的CMS构建的CMS/QAS纳米胶囊在模拟GIT液中的结肠定位释放性能较好，在不同饮料中储存7 d后，在GIT上部和结肠中的结肠定位释放率分别为33.04%~ 46.35%和52.70%~ 64.97%。这些发现表明，由具有较低DS和Mw的CMS构建的CMS/QAS纳米胶囊可以进一步开发作为潜在的蛋白质至结肠的口服递送系统。(C)2017爱思唯尔有限公司版权所有
Anionic carboxymethyl starch (CMS) and cationic quaternary ammonium starch (QAS), were used to fabricate nanocapsules through electrostatic layer by layer (LbL) alternate deposition onto colloidal BSA particles. An ideal starch-based colloidal nanocapsule was achieved by adjusting the degree of substitution (DS) and weight average molecular molar mass (M-w) of CMS. The nanocapsules fabricated by CMS with lower DS or Mw possessed more compact and stable core-shell structure, which favoured the BSA delivery from the upper gastrointestinal tract (GIT) to the colon. In particular, CMS/QAS nanocapsules constructed by CMS with lower DS and M-w showed better colon-specific delivery and release performance in simulated GIT fluid after 7 days' storage in different kinds of beverage (33.04%-46.35% in upper GIT, 52.70%-64.97% in colon, respectively). These findings demonstrated that CMS/QAS nanocapsules constructed by CMS with lower DS and Mw can be further exploited as a potential oral delivery system for protein to colon. (C) 2017 Elsevier Ltd. All rights reserved.