Skeletal stem cells and their contribution to skeletal fragility: senescence and rejuvenation.
Skeletal stem cells and their contribution to skeletal fragility: senescence and rejuvenation.
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DOI：
10.1007/s10522-015-9623-7
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发表时间：
2016-04
期刊：
影响因子：
4.5
通讯作者：
Aldahmash A
中科院分区：
文献类型：
--
作者：
Aldahmash A
与年龄相关的骨质疏松性骨折是世界范围内的主要医疗保健问题，是骨形成受损、骨量减少和骨脆性的结果。骨形成是通过从骨髓微环境募集到骨表面的骨骼干细胞（SSC）完成的。本综述讨论了在使用干细胞治疗与年龄相关的疾病的背景下，靶向 SSC 来增强骨形成并消除与年龄相关的骨脆性。最近的研究表明，由于内在的衰老相关变化以及衰老微环境的存在，SSC 在衰老过程中表现出功能受损。此外，还将介绍和讨论许多旨在通过靶向 SSC 来增加骨形成的方法，包括系统性 SSC 移植、使用适体或抗体的系统性 SSC 靶向、治疗性分泌组和组织工程方法的使用。
Age-related osteoporotic fractures are major health care problem worldwide and are the result of impaired bone formation, decreased bone mass and bone fragility. Bone formation is accomplished by skeletal stem cells (SSC) that are recruited to bone surfaces from bone marrow microenvironment. This review discusses targeting SSC to enhance bone formation and to abolish age-related bone fragility in the context of using stem cells for treatment of age-related disorders. Recent studies are presented that have demonstrated that SSC exhibit impaired functions during aging due to intrinsic senescence-related changes as well as the presence of senescent microenvironment. Also, a number of approaches aiming at increasing bone formation through targeting SSC and that include systemic SSC transplantation, systemic SSC targeting using aptamers or antibodies, use of therapeutic screteome and tissue engineering approaches will be presented and discussed.