Association of rs5764455 and rs6006473 polymorphisms in PARVB with liver damage of nonalcoholic fatty liver disease in Han Chinese population.
Association of rs5764455 and rs6006473 polymorphisms in PARVB with liver damage of nonalcoholic fatty liver disease in Han Chinese population.
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PARVB rs5764455和rs6006473多态性与中国汉族人群非酒精性脂肪肝肝损害的关系
DOI：
10.1016/j.gene.2015.09.007
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Wang Xiaoliang
中科院分区：
文献类型：
--
作者：
Wu Gang;Wang Kai;Xue Yingming;Song Guohe;Wang Yupeng;Sun Xing;Zhong Lin;Zhou Chongzhi;Shen Bing;Chen Jian;Yu Yang;Tang Huamei;Peng Zhihai;Sun Peichun;Wang Xiaoliang
背景非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝病之一，在中国汉族人群中的患病率正迅速上升。一些研究表明，PARVB基因的多态性可能在NAFLD的发展中起着至关重要的作用。因此，本研究旨在探讨PARVB基因rs 5764455和rs6006473多态性与中国汉族人群NAFLD易感性的关系。分析其临床资料及血清生化指标。结果PARVB基因rs 5764455 SNP位点AA型患者NAFLD的发生率高于AG型和GG型患者（分别为62.1%与50.3%和46.9%，p值= 0.034）。具有rs6006473 SNP的TT基因型的患者比具有CT和CC基因型的患者具有更高的NAFLD发病率（分别为56.9%对49.9%和42.0%，p值= 0.017）。rs 5764455 A等位基因和AA基因型与NAFLD的OR值分别为1.30和1.62，rs6006473 T等位基因和TT基因型与NAFLD的OR值分别为1.34和1.35。进一步分析显示，具有rs 5764455的AA基因型和rs6006473的TT基因型的患者具有更高的血浆甘油三酯、LDL-C、ALT和AST水平（p值< 0.05）。同样，rs 5764455基因型AA的患者中重度NAFLD的发生率高于基因型AG和GG的患者（分别为62.7% vs. 44.3%和43.0%，p值= 0.026）。rs6006473基因型TT患者中重度NAFLD的发生率高于基因型CT和CC患者（59.6%vs.46.6%，30.9%，p值= 0.001）结论本研究发现中国汉族人群PARVB基因rs 5764455和rs6006473多态性，这些多态性与NAFLD的发生和发展有关。
BackgroundNon-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, and its prevalence is rapidly increasing in Han Chinese individuals. Several studies have demonstrated that polymorphisms of the PARVB gene may play crucial roles in the development of NAFLD. Therefore, the present study was designed to investigate the association of rs5764455 and rs6006473 polymorphisms in PARVB with the Han Chinese population's susceptibility to NAFLD.MethodsA total of 384 cases of NAFLD patients and 384 healthy controls were enrolled in this study. Their clinical information and serum biochemical indexes were analyzed. A sample (5 ml) of fasting venous blood was taken from each subject for DNA extraction, after which SNP probes were customized, and real-time PCR was used to detect SNP in the PARVB gene.ResultsPatients with genotype AA of rs5764455 SNP locus in PARVB gene had a higher incidence of NAFLD than patients with genotypes AG and GG (62.1% vs. 50.3% and 46.9%, respectively, p-values = 0.034). Patients with genotype TT of rs6006473 SNP had a higher incidence of NAFLD than patients with genotypes CT and CC (56.9% vs. 49.9% and 42.0%, respectively, p-values = 0.017). The ORs of the A allele and AA genotype of rs5764455 for NAFLD were 1.30 and 1.62, respectively; those of the T allele and TT genotype of rs6006473 for NAFLD were 1.34 and 1.35, respectively. Further analysis revealed that patients with genotype AA of rs5764455 and genotype TT of rs6006473 had higher levels of plasma triglyceride, LDL-C, ALT and AST (p-values < 0.05). Likewise, patients with genotype AA of rs5764455 had a higher incidence of moderate to severe NAFLD than patients with genotypes AG and GG (62.7% vs. 44.3% and 43.0%, respectively, p-values = 0.026). Patients with genotype TT of rs6006473 had a higher incidence of moderate to severe NAFLD than patients with genotypes CT and CC (59.6% vs. 46.6% and 30.9%, respectively, p-values = 0.001).ConclusionsOur study found polymorphisms of rs5764455 and rs6006473 in PARVB gene in the Han Chinese population, and these polymorphisms were associated with the occurrence and progression of NAFLD.
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DOI：
10.1007/s11938-004-0001-9
发表时间：
2004
期刊：
Current Treatment Options in Gastroenterology
影响因子：
--
作者：
B. Mulhall;Z. Younossi
通讯作者：
B. Mulhall;Z. Younossi
影响因子：
--
作者：
S. Kechagias;M. Ekstedt
通讯作者：
S. Kechagias;M. Ekstedt
影响因子：
4.5
作者：
Speliotes EK;Yerges-Armstrong LM;Wu J;Hernaez R;Kim LJ;Palmer CD;Gudnason V;Eiriksdottir G;Garcia ME;Launer LJ;Nalls MA;Clark JM;Mitchell BD;Shuldiner AR;Butler JL;Tomas M;Hoffmann U;Hwang SJ;Massaro JM;O'Donnell CJ;Sahani DV;Salomaa V;Schadt EE;Schwartz SM;Siscovick DS;NASH CRN;GIANT Consortium;MAGIC Investigators;Voight BF;Carr JJ;Feitosa MF;Harris TB;Fox CS;Smith AV;Kao WH;Hirschhorn JN;Borecki IB;GOLD Consortium
通讯作者：
GOLD Consortium
中国汉族人群肝脏表达数量性状位点 (eQTL) 的定位。
影响因子：
4
作者：
Wang X;Tang H;Teng M;Li Z;Li J;Fan J;Zhong L;Sun X;Xu J;Chen G;Chen D;Wang Z;Xing T;Zhang J;Huang L;Wang S;Peng X;Qin S;Shi Y;Peng Z
通讯作者：
Peng Z
影响因子：
29.4
作者：
Chalasani N;Guo X;Loomba R;Goodarzi MO;Haritunians T;Kwon S;Cui J;Taylor KD;Wilson L;Cummings OW;Chen YD;Rotter JI;Nonalcoholic Steatohepatitis Clinical Research Network
通讯作者：
Nonalcoholic Steatohepatitis Clinical Research Network