Rapid signaling of steroid hormones in the vertebrate nervous system
Rapid signaling of steroid hormones in the vertebrate nervous system
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DOI：
10.2741/3970
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发表时间：
2012-01-01
影响因子：
3.1
通讯作者：
Kawata, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Sakamoto, Hirotaka;Takahashi, Hideya;Kawata, Mitsuhiro
类固醇激素很容易通过血脑屏障，因为它们具有物理化学脂溶性。这些激素通过核受体介导的机制发挥作用，并调节基因转录。与其基因组作用不同的是，类固醇激素通过各种类型的膜相关受体发挥作用的非基因组快速作用，揭示了不同于细胞内核受体作用的药理学特性。因此，非基因组的快速行动获得了越来越多的科学兴趣。然而，对类固醇在大脑中的系统发生和/或比较作用的洞察仍然知之甚少。在这篇综述中，我们总结了关于脊椎动物中枢神经系统中类固醇激素快速、非基因组信号传递的最新发现，并讨论了最近发表的关于生理和行为机制的数据(从鱼类到哺乳动物的比较观点)。
Steroid hormones easily cross the blood-brain barrier because of their physicochemical lipid solubility. The hormones act through nuclear receptor-mediated mechanisms and modulate gene transcription. In contrast to their genomic actions, the non-genomic rapid action of steroid hormones, acting via various types of membrane-associated receptors, reveals pharmacological properties that are distinct from the actions of the intracellular nuclear receptors. As a result, non-genomic rapid actions have gained increased scientific interest. However, insight into the phylogenic and/or comparative actions of steroids in the brain is still poorly understood. In this review, we summarize recent findings concerning the rapid, non-genomic signaling of steroid hormones in the vertebrate central nervous system, and we discuss (using a comparative view from fish to mammals) recently published data regarding the mechanism underlying physiology and behavior.