Reducing HIV transmission risk by increasing serostatus disclosure: A mathematical modeling analysis
Reducing HIV transmission risk by increasing serostatus disclosure: A mathematical modeling analysis
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DOI：
10.1007/s10461-006-9187-2
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发表时间：
2007-09-01
影响因子：
4.4
通讯作者：
Galletly, Carol L.
中科院分区：
文献类型：
--
作者：
Pinkerton, Steven D.;Galletly, Carol L.
鼓励艾滋病毒感染者向未来的性伴侣透露其艾滋病毒血清阳性状况，以减少不安全性行为和艾滋病毒传播的可能性。然而，公开血清状况作为一项预防措施的有效性尚不清楚。我们开发了一个数学框架来评估艾滋病毒传播风险降低的有效性的血清状态披露，研究如何增加披露率影响的传播风险降低披露的有效性，并探讨安全套的使用和披露的有效性之间的相互作用。在基本情况假设下，相对于不披露，披露血清状况将艾滋病毒传播的风险降低了17.9%至40.6%。从51.9%-75.7%的基础案例值增加披露率，风险降低了26.2%-59.2%。这项模拟研究的结果强烈支持干预措施，以增加艾滋病毒感染者的血清状态披露和安全套的使用。
Persons living with HIV infection are encouraged to disclose their HIV-positive serostatus to prospective sex partners to decrease the likelihood of unsafe sex and HIV transmission. However, the effectiveness of serostatus disclosure as a preventive measure is not known. We developed a mathematical framework for assessing the HIV transmission risk reduction effectiveness of serostatus disclosure, examined how increasing the disclosure rate affects the transmission risk reduction effectiveness of disclosure, and explored the interaction between condom use and disclosure effectiveness. Under base-case assumptions, serostatus disclosure reduced the risk of HIV transmission by between 17.9% and 40.6% relative to no disclosure. Increasing the disclosure rate from the base-case value of 51.9-75.7% produced a 26.2-59.2% reduction in risk. The findings of this modeling study strongly support intervention efforts to increase both serostatus disclosure and condom use by persons living with HIV.