Demonstration of potential noninvasive ultrasound brain therapy through an intact skull
Demonstration of potential noninvasive ultrasound brain therapy through an intact skull
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DOI：
10.1016/s0301-5629(97)00269-x
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发表时间：
1998-02-01
影响因子：
2.9
通讯作者：
Jolesz, FA
中科院分区：
文献类型：
--
作者：
Hynynen, K;Jolesz, FA
治疗性超声波在大脑中的应用受到普遍接受的观点的严重限制，即这些暴露将需要去除一块颅骨以允许超声波束传播到大脑中。在本文中，通过完整的颅骨提供超声治疗的可行性进行了研究。超声进行了通过一块人颅骨与聚焦换能器在0.248，0.559 1.0和1.68 MHz。颅骨衰减并扭曲了场;然而，在1 MHz或更低的频率下产生了尖锐的焦点。在更高的频率下，焦点被破坏了。为了研究补偿骨引起的超声场失真的可行性，进行了相控阵实验。在这些实验中使用了两个具有64个元件的阵列，工作在0.6 MHz和1.58 MHz。由头骨引起的相移被测量为阵列的每个元件，然后由相位控制电路补偿。这些相位校正允许在两个频率下产生尖锐的焦点。最后，通过在0.559 MHz的频率下使用脉冲超声处理穿过兔脑中的一块人颅骨来诱导组织破坏。总之，结果表明，经颅递送治疗性超声进入大脑可能是可行的。(C)1998年世界医学和生物学超声联合会。
Utilization of therapeutic ultrasound in the brain has been seriously limited by the commonly accepted view that these exposures would require that a piece of the skull bone be removed to allow the ultrasound beam to propagate into the brain. In this paper, the feasibility of delivering ultrasound therapy through the intact skull was studied. Sonications were performed through a piece of human skull with focused transducers at 0.248, 0.559 1.0 and 1.68 MHz. The skull attenuated and distorted the field; however, a sharp focal spot was created at frequencies of 1 MHz or lower. At the higher frequency, the focus was destroyed. To investigate the feasibility of compensating for the ultrasound field distortion caused by the bone, phased array experiments were performed. Two arrays with 64 elements, operating at 0.6 MHz and 1.58 MHz, were used in these experiments. The phase shifts caused by the skull were measured for each element of the arrays and then compensated for by phase-control circuitry. These phase corrections allowed a sharp focus to be generated at both frequencies. Finally, tissue destruction was induced by using pulsed sonication through a piece of human skull in a rabbit brain in vivo at the frequency of 0.559 MHz. In summary, the results showed that transcranial delivery of therapeutic ultrasound into the brain may be feasible. (C) 1998 World Federation for Ultrasound in Medicine & Biology.