Modest efficacy of voriconazole against murine infections by Sporothrix schenckii and lack of efficacy against Sporothrix brasiliensis
Modest efficacy of voriconazole against murine infections by Sporothrix schenckii and lack of efficacy against Sporothrix brasiliensis
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DOI：
10.1111/myc.12112
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发表时间：
2014-02-01
期刊：
影响因子：
4.9
通讯作者：
Guarro, Josep
中科院分区：
文献类型：
--
作者：
Fernandez-Silva, Fabiola;Capilla, Javier;Guarro, Josep
采用小鼠播散性感染模型，评价伏立康唑(VRC)对引起孢子丝菌病的两个最常见种--申克孢子丝菌(Sporothrix Schenckii Sensu Strato To)和巴西孢子丝菌(Sporothrix Brasiliens)的疗效。伏立康唑每天20或40 mg·kg~(-1)灌胃给药。该药在延长申克链球菌感染小鼠的存活时间和降低脾、肝真菌负荷方面表现出一定的疗效，尤其是每天40mgkg(-1)，而对感染巴西葡萄球菌的动物则无效。
The efficacy of voriconazole (VRC) was evaluated against two strains of each of the two most common species causing sporotrichosis, Sporothrix schenckii sensu stricto and Sporothrix brasiliensis, using a murine model of disseminated infection. Voriconazole was administered at doses of 20 or 40mgkg(-1) per day by gavage. The drug showed some efficacy, especially at 40mgkg(-1) per day, in prolonging the survival and reducing fungal load in spleen and liver in mice infected with S. schenckii, whereas in animals infected with S. brasiliensis the drug did not work.