Separate and Shared Neural Basis of Face Memory and Face Perception in Developmental Prosopagnosia.
Separate and Shared Neural Basis of Face Memory and Face Perception in Developmental Prosopagnosia.
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发育性面容失认中面部记忆和面部感知的独立和共享神经基础
DOI：
10.3389/fnbeh.2021.668174
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发表时间：
2021
影响因子：
3
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Liu X;Li X;Song Y;Liu J
发展性面容失认症（DP），也称为脸盲，是一种认知障碍，在识别面孔方面存在严重缺陷。然而，DP的异质性导致了关于哪些阶段出现赤字的长期争论，面部感知（例如，匹配两个连续呈现的面部）或面部记忆（例如，将面部与记忆的面部相匹配）。在这里，我们使用个体差异的方法与功能磁共振成像，探讨的神经基板的DP的面孔知觉和面孔记忆，可能阐明DP的异质性。具体来说，我们测量了大样本的个人患有DP（N = 64）的行为表现的面孔知觉和面孔记忆，然后将其面部选择性的神经反应的核心面孔网络（CFN）和扩展的面孔网络（EFN）的行为表现，分别。行为上，我们发现，DP个人受损的面孔知觉和面孔记忆，但是，只有一个弱相关的性能之间的两个任务。与此相一致的是，DP在面孔记忆任务中的表现的神经相关定位于双侧梭状面孔区，而DP在面孔感知任务中的表现与右后上级颞上沟的面孔选择性相关，这表明DP的CFN中用于面孔记忆和面孔感知的神经基质是分开的。相反，在EFN中确定了面部感知和面部记忆任务中的缺陷的共享神经基质，包括右楔前叶和右眶额皮质。总之，我们的研究提供了第一个经验证据，分别在CFN和EFN中识别了面部感知和面部记忆的独立和共享神经基质，这可能有助于阐明DP的异质性。
Developmental prosopagnosia (DP), also known as face blindness, is a cognitive disorder with a severe deficit in recognizing faces. However, the heterogeneous nature of DP leads to a longstanding debate on which stages the deficit occurs, face perception (e.g., matching two consecutively presented faces) or face memory (e.g., matching a face to memorized faces). Here, we used the individual difference approach with functional magnetic resonance imaging to explore the neural substrates of DPs’ face perception and face memory that may illuminate DPs’ heterogeneity. Specifically, we measured the behavioral performance of face perception and face memory in a large sample of individuals suffering DP (N = 64) and then associated the behavioral performance with their face-selective neural responses in the core face network (CFN) and the extended face network (EFN), respectively. Behaviorally, we found that DP individuals were impaired in both face perception and face memory; however, there was only a weak correlation between the performances of two tasks. Consistent with this observation, the neural correlate of DPs’ performance in face memory task was localized in the bilateral fusiform face area, whereas DPs’ performance in face perception task was correlated with the face selectivity in the right posterior superior temporal sulcus, suggesting that the neural substrates in the CFN for face memory and face perception were separate in DP. In contrast, shared neural substrates of deficits in face perception and face memory tasks were identified in the EFN, including the right precuneus and the right orbitofrontal cortex. In summary, our study provides one of the first empirical evidence that the separate and shared neural substrates of face perception and face memory were identified in the CFN and EFN, respectively, which may help illuminating DP’s heterogeneous nature.
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