Fluoride dentifrice ingestion and fluorosis, of the permanent incisors
Fluoride dentifrice ingestion and fluorosis, of the permanent incisors
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DOI：
10.14219/jada.archive.2006.0261
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发表时间：
2006-05-01
影响因子：
3.9
通讯作者：
Broffitt, Barbara
中科院分区：
文献类型：
--
作者：
Franzman, Michael R.;Levy, Steven M.;Broffitt, Barbara
背景。含氟牙膏是预防儿童龋齿的主要手段，但它也是氟中毒的一个重要危险因素。本文探讨了含氟牙膏对恒切牙氟中毒的影响。爱荷华氟化物研究的参与者定期收到关于氟化物来源的问卷。作者使用氟中毒风险指数评估氟中毒。他们估计了每天从牙膏、饮食和氟化物补充剂中摄入的氟化物，并将摄入量除以体重公斤数。氟摄入与恒切牙氟中毒关系的统计分析。在双变量分析中，轻度氟中毒与24个月和36个月时摄入含氟牙膏显著相关（两者P = 0.02）。在校正了饮食来源的氟化物摄入后，logistic回归显示24月龄氟中毒与牙膏摄入之间存在显著相关性（P = 0.04）。研究结果表明，恒门牙氟中毒与三岁前摄入含氟牙膏有关。需要进一步的研究来评估氟的总摄入量作为氟中毒的一个危险因素。临床意义。这些结果支持了幼儿只使用豌豆大小的牙膏的建议。家长应监督幼儿用含氟牙膏刷牙。
Background. Fluoride dentifrice is a primary means of preventing childhood caries, but it is also an important risk factor for fluorosis. The authors examine the influence of fluoride dentifrice ingesting on fluorosis of the permanent incisors.Methods. Participants in the Iowa Fluoride Study received questionnaires at regular intervals concerning fluoride sources. The authors assessed fluorosis using the fluorosis risk index. They estimated daily fluoride ingestion from dentifrice, diet and fluoride supplements and divided the amount by kilograms of body weight. The statistical analysis related fluoride ingestion to fluorosis in the permanent incisors.Results. In bivariate analyses, mild fluorosis was significantly related to ingestion of fluoride dentifrice at ages 24 and 36 months (P = .02 for both). After the authors adjusted for fluoride ingested from dietary sources, logistic regression showed a significant association between fluorosis and dentifrice ingestion at age 24 months (P = .04).Conclusions. The study results suggest the fluorosis of the permanent incisors is influenced by ingestion of fluoride dentifrice during the first three years of life. Further research is needed to assess total intake of fluoride as a risk factor for fluorosis.Clinical Implications. These results support recommendations that young children use only a pea-sized amount of dentifrice. Parents should supervise young children as they brush their teeth with fluoride dentifrice.