Neural Representations of Unconditioned Stimuli in Basolateral Amygdala Mediate Innate and Learned Responses.
Neural Representations of Unconditioned Stimuli in Basolateral Amygdala Mediate Innate and Learned Responses.
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DOI：
10.1016/j.cell.2015.06.027
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发表时间：
2015-07-02
期刊：
影响因子：
64.5
通讯作者：
Axel R
中科院分区：
文献类型：
--
作者：
Gore F;Schwartz EC;Brangers BC;Aladi S;Stujenske JM;Likhtik E;Russo MJ;Gordon JA;Salzman CD;Axel R
具有内在奖励或厌恶性质的刺激引起情绪反应，并通过在中性感觉线索上赋予效价来诱导学习。越来越多的证据表明杏仁核是介导这些过程的关键结构。我们已经开发了一种遗传策略，以确定代表性的奖励和厌恶的无条件刺激（US）在基底外侧杏仁核（BLA），并已检查其在先天和后天反应的作用。在BLA中的US反应细胞的集合体的激活激发了不同效价的先天生理和行为反应。当与不同的中性刺激配对时，这种US合奏的激活也可以加强食欲和厌恶学习。此外，我们建立了在BLA中的US响应细胞的激活是必要的条件反应的表达。因此，条件刺激和非条件刺激的神经表征最终必须连接到BLA中的US反应细胞，以引起先天和后天反应。
Stimuli that possess inherently rewarding or aversive qualities elicit emotional responses and also induce learning by imparting valence upon neutral sensory cues. Evidence has accumulated implicating the amygdala as a critical structure in mediating these processes. We have developed a genetic strategy to identify the representations of rewarding and aversive unconditioned stimuli (USs) in the basolateral amygdala (BLA) and have examined their role in innate and learned responses. Activation of an ensemble of US-responsive cells in the BLA elicits innate physiological and behavioral responses of different valence. Activation of this US ensemble can also reinforce appetitive and aversive learning when paired with differing neutral stimuli. Moreover, we establish that the activation of US-responsive cells in the BLA is necessary for the expression of a conditioned response. Neural representations of conditioned and unconditioned stimuli must therefore ultimately connect to US-responsive cells in the BLA to elicit both innate and learned responses.