Natural killer cells: Detectors of stress
Natural killer cells: Detectors of stress
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DOI：
10.1016/j.biocel.2008.05.001
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发表时间：
2008-01-01
影响因子：
4
通讯作者：
Tomasello, Elena
中科院分区：
文献类型：
--
作者：
Luci, Carmelo;Tomasello, Elena
自然杀伤（NK）细胞是先天免疫系统的关键组成部分，因为它们能够检测微生物感染的细胞，肿瘤以及同种异体细胞，而无需特异性致敏。NK细胞效应子功能（细胞毒性、细胞因子分泌）由多种抑制性和活化性受体调节。MHC I类分子是大多数抑制性受体的配体，而激活性受体识别病原体编码的分子或自身蛋白，其表达在微生物感染或肿瘤发展时上调。在整合这些阴性和阳性信号后，自然杀伤细胞可以区分健康的“自身”（耐受性）和经历不同类型细胞应激的自体细胞或同种异体细胞（免疫监视）。因此，了解靶细胞识别的不同机制对于剖析NK细胞参与稳态和疾病状况以及开发基于NK细胞操作的新型替代治疗方法至关重要。(C)2008爱思唯尔有限公司保留所有权利。
Natural killer (NK) cells are a key component of the innate immune system, as they are able to detect microbe-infected cells, tumors as well as allogeneic cells, without specific sensitization. NK cell effector functions (cytotoxicity, cytokine secretion) are regulated by a wide array of inhibitory and activating receptors. MHC class I molecules are the ligands of most inhibitory receptors, while activating receptors recognize either pathogen-encoded molecules, or self-proteins whose expression is up-regulated upon microbial infection or tumor development. Upon integration of these negative and positive signals, Natural Killer cells can discriminate between healthy "self" (tolerance) and autologous cells undergoing different types of cellular stress or allogeneic cells (immunosurveillance). The knowledge of the different mechanisms of target cell recognition is thus crucial to dissect NK cell involvement in homeostatic and disease conditions as well as to develop novel alternative therapeutic approaches based on NK cell manipulation. (C) 2008 Elsevier Ltd. All rights reserved.