Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder
Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder
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DOI：
10.1016/j.biopsych.2005.12.012
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发表时间：
2007-02-01
影响因子：
10.6
通讯作者：
Wilhelm, Sabine
中科院分区：
文献类型：
--
作者：
Rauch, Scott L.;Wedig, Michelle M.;Wilhelm, Sabine
背景：皮质神经回路与强迫症（OCD）的病理生理有关.序列反应时（SRT）任务，一个范式，测试内隐序列学习，已被用于与成像探测纹状体功能。初步研究表明，与健康对照（HC）受试者相比，强迫症患者表现出纹状体激活不足和海马募集异常。在这里，我们使用的SRT和功能磁共振成像（fMRI）复制以前的结果在一个更大的样本，并测试区域激活和OCD症状dimensions.Methods之间的关系：使用SPM 99，fMRI-SRT数据从12个强迫症和12个匹配的HC科目进行了分析。症状维度遵循四因素模型，以0- 10分量表评分。对于内隐学习与随机对照，组间条件相互作用揭示了双头体和眶额皮质（OCD > HC）内的异常募集，但纹状体组间无差异。然而，纹状体激活与特定症状因子之间存在负相关。这些结果重复了以前的小规模研究，显示在SRT表现过程中OCD的海马募集异常。虽然研究结果的缺陷纹状体激活强迫症没有复制，相关性结果表明，这种不一致性可能是由于强迫症症状维度之间的差异。
Background: Corticosthatal circuitry has been implicated in the pathophysiology of obsessive- compulsive disorder (OCD). The serial reaction time (SRT) task, a paradigm that tests implicit sequence learning, has been used with imaging to probe striatal function. Initial studies have indicated that OCD patients exhibit deficient striatal activation and aberrant hippocampal recruitment compared with healthy control (HC) subjects. Here, we used the SRT and functional magnetic resonance imaging (fMRI) to replicate prior results in a larger sample and to test for relationships between regional activation and OCD symptom dimensions.Methods: Using SPM99, fMRI-SRT data from 12 OCD and 12 matched HC subjects were analyzed. Symptom dimensions followed a four-factor model scored on a 0- to 10-point scale.Results. For the implicit learning versus random contrast, group by condition interactions revealed aberrant recruitment within the bippocampus as well as orbitofrontal cortex (OCD > HC) but no striatal group differences. However, an inverse correlation was found between striatal activation and specific symptom fiactors.Conclusions. These results replicate previous smaller studies showing aberrant hippocampal recruitment in OCD during SRT performance. Although findings of deficient striatal activation in OCD were not replicated, correlation results suggest that this inconsistency may be attributable to differences among OCD symptom dimensions.