Sterile inflammation in liver transplantation.
Sterile inflammation in liver transplantation.
复制标题
肝移植中的无菌炎症。
DOI：
10.3389/fmed.2023.1223224
复制
发表时间：
2023
影响因子：
3.9
通讯作者：
Barbas, Andrew S.
中科院分区：
文献类型：
--
作者：
Kahan, Riley;Cray, Paul L.;Abraham, Nader;Gao, Qimeng;Hartwig, Matthew G.;Pollara, Justin J.;Barbas, Andrew S.
关键词：
无菌性炎症是在没有外来病原体的情况下，对细胞死亡期间释放的损伤相关分子模式（DAMP）的免疫反应。在实体器官移植的情况下，缺血-再灌注损伤导致细胞介导的活性氧和氮物质的产生，这是不受控制的细胞死亡和各种DAMP从移植物组织释放的主要原因。当适当调节时，由DAMP传感引发的免疫应答充当损伤控制的手段，并且对于恢复途径的启动和稳态的重建是必要的。相比之下，失调或明显的无菌炎症反应可通过免疫细胞的募集、先天免疫细胞活化和适应性免疫系统的致敏而无意中导致进一步损伤。在肝移植中，无菌性炎症可能表现为早期移植物功能障碍、急性移植物衰竭或免疫抑制剂抵抗性排斥反应风险增加。了解肝移植环境中无菌性炎症发展的机制对于寻找预测移植物功能的可靠生物标志物以及开发改善长期移植结局的治疗方法至关重要。在这里，我们讨论了最近取得的进展，阐明了无菌性炎症的早期迹象和损伤程度，我们还讨论了新的治疗方法，可能是有效的平息无菌性炎症的有害影响。
Sterile inflammation is the immune response to damage-associated molecular patterns (DAMPs) released during cell death in the absence of foreign pathogens. In the setting of solid organ transplantation, ischemia-reperfusion injury results in mitochondria-mediated production of reactive oxygen and nitrogen species that are a major cause of uncontrolled cell death and release of various DAMPs from the graft tissue. When properly regulated, the immune response initiated by DAMP-sensing serves as means of damage control and is necessary for initiation of recovery pathways and re-establishment of homeostasis. In contrast, a dysregulated or overt sterile inflammatory response can inadvertently lead to further injury through recruitment of immune cells, innate immune cell activation, and sensitization of the adaptive immune system. In liver transplantation, sterile inflammation may manifest as early graft dysfunction, acute graft failure, or increased risk of immunosuppression-resistant rejection. Understanding the mechanisms of the development of sterile inflammation in the setting of liver transplantation is crucial for finding reliable biomarkers that predict graft function, and for development of therapeutic approaches to improve long-term transplant outcomes. Here, we discuss the recent advances that have been made to elucidate the early signs of sterile inflammation and extent of damage from it. We also discuss new therapeutics that may be effective in quelling the detrimental effects of sterile inflammation.
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DOI：
10.1097/shk.0000000000001969
发表时间：
2022-09-01
期刊：
Shock (Augusta, Ga.)
影响因子：
--
作者：
通讯作者：
--
影响因子：
6
作者：
Andersson U;Tracey KJ;Yang H
通讯作者：
Yang H
影响因子：
7.3
作者：
Chen Y;Zhang W;Bao H;He W;Chen L
通讯作者：
Chen L
DOI：
10.1111/ajt.12727
发表时间：
2014-06
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Bruinsma BG;Yeh H;Ozer S;Martins PN;Farmer A;Wu W;Saeidi N;Op den Dries S;Berendsen TA;Smith RN;Markmann JF;Porte RJ;Yarmush ML;Uygun K;Izamis ML
通讯作者：
Izamis ML
DOI：
10.1111/ajt.15023
发表时间：
2019-01
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Baroja-Mazo A;Revilla-Nuin B;de Bejar Á;Martínez-Alarcón L;Herrero JI;El-Tayeb A;Müller CE;Aparicio P;Pelegrín P;Pons JA
通讯作者：
Pons JA