Release Rate Studies of 5-Aminosalacylic Acid Coated with Atomic Layer-Deposited Al 2 O 3 and ZnO in an Acidic Environment
Release Rate Studies of 5-Aminosalacylic Acid Coated with Atomic Layer-Deposited Al 2 O 3 and ZnO in an Acidic Environment
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原子层沉积Al 2 O 3 和ZnO包覆的5-氨基水杨酸在酸性环境中的释放速率研究
DOI：
10.1021/acsabm.2c00750
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发表时间：
2023
影响因子：
4.7
通讯作者：
Banerjee, Parag
中科院分区：
文献类型：
--
作者：
Sosa, Jaynlynn;Berriel, S. Novia;Feit, Corbin;Currie, Taylor M.;Shultz, Lorianne R.;Rudawski, Nicholas G.;Jurca, Titel;Banerjee, Parag
5-氨基水杨酸（5-阿萨）是用于治疗轻度炎症性肠病的一线防御药物。当口服给药时，活性药物成分在整个胃肠道释放，缓解慢性炎症。然而，5-阿萨的延迟和靶向释放系统在酸性环境中实现最佳剂量体积仍然是一个挑战。在这里，我们展示了应用原子层沉积（ALD）作为一种技术来合成5-阿萨纳米涂层，以控制其在酸性介质中的释放。ALD Al 2 O3（38.0 nm）和ZnO（24.7 nm）膜在旋转热ALD系统中沉积在1 g批料5-阿萨粉末上。傅里叶变换红外光谱、扫描电子显微镜和扫描/透射电子显微镜建立了ALD涂层在5-阿萨颗粒上的界面化学和保形性质。当Al 2 O3与5-阿萨形成尖锐界面时，ZnO似乎扩散到5-阿萨内部。通过紫外-可见光谱法研究了5-阿萨在pH 4溶液中的释放。模拟肠道蠕动的动态搅拌导致Al 2 O3包覆颗粒的机械磨损，从而释放5-阿萨。然而，在持续5000 s的静态条件下，与ZnO涂层的100%释放相比，Al 2 O3涂覆的颗粒仅释放17.5%的5-阿萨。基于石英晶体微天平的蚀刻研究证实了Al 2 O3在pH 4介质中的稳定性，其中ZnO薄膜的蚀刻速度比Al 2 O3快41倍。这样的结果对于实现在酸性环境中具有受控释放的用于5-阿萨的纳米级基于包衣的药物递送系统是重要的。
5-Aminosalicylic acid (5-ASA) is a first-line defense drug used to treat mild cases of inflammatory bowel disease. When administered orally, the active pharmaceutical ingredient is released throughout the gastrointestinal tract relieving chronic inflammation. However, delayed and targeted released systems for 5-ASA to achieve optimal dose volumes in acidic environments remain a challenge. Here, we demonstrate the application of atomic layer deposition (ALD) as a technique to synthesize nanoscale coatings on 5-ASA to control its release in acidic media. ALD Al2O3(38.0 nm) and ZnO (24.7 nm) films were deposited on 1 g batch powders of 5-ASA in a rotatory thermal ALD system. Fourier transform infrared spectroscopy, scanning electron microscopy, and scanning/transmission electron microscopy establish the interfacial chemistry and conformal nature of ALD coating over the 5-ASA particles. While Al2O3forms a sharp interface with 5-ASA, ZnO appears to diffuse inside 5-ASA. The release of 5-ASA is studied in a pH 4 solution via UV–vis spectroscopy. Dynamic stirring, mimicking gut peristalsis, causes mechanical attrition of the Al2O3-coated particles, thereby releasing 5-ASA. However, under static conditions lasting 5000 s, the Al2O3-coated particles release only 17.5% 5-ASA compared to 100% release with the ZnO coating. Quartz crystal microbalance-based etch studies confirm the stability of Al2O3in pH 4 media, where the ZnO films etch 41× faster than Al2O3. Such results are significant in achieving a nanoscale coating-based drug delivery system for 5-ASA with controlled release in acidic environments.