HBV/HCV co-infection is associated with a high level of HCV spontaneous clearance among drug users and blood donors in China
HBV/HCV co-infection is associated with a high level of HCV spontaneous clearance among drug users and blood donors in China
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中国吸毒者和献血者中乙型肝炎病毒/丙型肝炎病毒合并感染与高水平的丙型肝炎病毒自发清除有关
DOI：
10.1111/jvh.12644
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发表时间：
2017
影响因子：
2.5
通讯作者：
Fu Y.
中科院分区：
文献类型：
--
作者：
Xiong H.;Rong X.;Wang M.;Xu R.;Huang K.;Liao Q.;Huang J.;Chen J.;Li C.;Tang X.;Shan Z.;Zhang M.;Nelson K.;Fu Y.
了解丙型肝炎病毒（HCV）感染的自发清除的生物学可能会导致改进的策略，以防止与慢性HCV感染相关的后遗症。慢性肝炎病毒感染在中国非常常见，但与HCV自发清除相关的因素尚未得到充分研究。我们评估了中国广州1918名吸毒者和1526名HCV血清阳性献血者的HCV自发清除率。在合并感染B型肝炎病毒（HBV）的参与者中，41.38%的吸毒者和39.47%的献血者在没有抗病毒治疗的情况下清除了HCV感染，而吸毒者和献血者中只有9.41%的人感染了单一病毒（P<.01）。血清HBV DNA> 2000 IU/mL的合并感染受试者中清除HCV感染的受试者比例显著高于血清HBV DNA水平较低的受试者。多元逻辑回归分析发现，女性性别、IL 28 B rs 8099917 TT基因型、HBV合并感染和献血者（vs吸毒者）与HCV感染的自发清除率增加相关。虽然急性HCV感染在中国很常见，但在中国人群中，慢性HBV和IL 28 B基因型的高患病率可能会降低慢性HCV的发病率，这些基因型与HCV的自发清除相关。
Understanding the biology of spontaneous clearance of hepatitis C virus (HCV) infection could lead to improved strategies to prevent the sequelae associated with chronic HCV infection. Chronic infections with hepatitis virus are very common in China, but the factors associated with spontaneous clearance of HCV have not been adequately studied. We evaluated the spontaneous clearance of HCV among 1918 drug users and 1526 HCV‐seropositive blood donors in Guangzhou, China. Among participants who were co‐infected with hepatitis B virus (HBV), 41.38% of drug users and 39.47% of blood donors had cleared their HCV infection without antiviral therapy compared to 9.41% of drug users and 16.73% of blood donors who were mono‐infected with a single virus (P<.01). The proportion of subjects who had cleared their HCV infection was significantly greater in the co‐infected subjects whose serum HBV DNA was greater than 2000IU/mL than those with lower levels. A multiple logistic regression analysis found female gender, IL28B rs8099917 TT genotype, HBV co‐infection and blood donors (vs drug users) associated with increased spontaneous clearance of HCV infection. Although acute HCV infections are common in China, the incidence of chronic HCV may be reduced among the high prevalence of chronic HBV and IL28B genotypes associated with spontaneous clearance of HCV in Chinese populations.