Area-Specificity and Plasticity of History-Dependent Value Coding During Learning
Area-Specificity and Plasticity of History-Dependent Value Coding During Learning
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DOI：
10.1016/j.cell.2019.04.027
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发表时间：
2019-06-13
期刊：
影响因子：
64.5
通讯作者：
Komiyama, Takaki
中科院分区：
文献类型：
--
作者：
Hattori, Ryoma;Danskin, Bethanny;Komiyama, Takaki
决策通常是由可选选项的主观价值驱动的，这种价值是通过经验形成的。为了支持这种基本行为，大脑必须对主观价值进行编码和维护。为了研究价值编码的区域特异性和可塑性，我们对小鼠进行了基于价值的决策任务训练，并对6个皮质区域的神经活动进行了细胞分辨率成像。与历史和价值相关的信号在各个地区都很普遍，但它们的强度和时间模式不同。在专家小鼠中，脾后皮层（RSC）在试验中以持续的种群活动模式独特地编码历史和价值相关信号。这种独特的RSC编码出现在任务学习过程中，更遥远的历史信号显著增加。RSC的急性失活选择性地损害了基于奖励历史的行为策略。我们的研究结果表明，RSC灵活地改变其历史编码，并持续编码价值相关信号，以支持自适应行为。
Decision making is often driven by the subjective value of available options, a value which is formed through experience. To support this fundamental behavior, the brain must encode and maintain the subjective value. To investigate the area specificity and plasticity of value coding, we trained mice in a value-based decision task and imaged neural activity in 6 cortical areas with cellular resolution. History- and value-related signals were widespread across areas, but their strength and temporal patterns differed. In expert mice, the retrosplenial cortex (RSC) uniquely encoded history- and value-related signals with persistent population activity patterns across trials. This unique encoding of RSC emerged during task learning with a strong increase in more distant history signals. Acute inactivation of RSC selectively impaired the reward-history-based behavioral strategy. Our results indicate that RSC flexibly changes its history coding and persistently encodes value-related signals to support adaptive behaviors.