Blood conservation with tranexamic acid in total hip arthroplasty - A randomized, double-blind study in 40 primary operations
Blood conservation with tranexamic acid in total hip arthroplasty - A randomized, double-blind study in 40 primary operations
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DOI：
10.1080/000164701753532754
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发表时间：
2001-10-01
期刊：
影响因子：
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通讯作者：
Nilsson, P
中科院分区：
文献类型：
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作者：
Benoni, G;Fredin, H;Nilsson, P
我们进行了一项随机、双盲研究，研究氨甲环酸对40例原发性全髋关节置换术患者失血和输血的影响。术前静脉给予氨甲环酸，每公斤体重10mg，或安慰剂。记录术中及术后引流的出血量，同时记录血红蛋白浓度。术后1周行超声检查，估计剩余血肿导致的出血量。氨甲环酸组（手术+引流）总出血量为0.76 (95% CI 0.63-0.89) L，而安慰剂组为1.0 (CI 0.81-1.2) L （p = 0.03）。手术当日输血次数2次vs. 10次（p = 0.07），住院总输血次数5次vs. 13次（p = 0.2）。两组各1例发生肺栓塞。
We performed a randomized, double-blind study on the effect of tranexamic acid on blood loss and blood transfusions in 40 primary total hip arthroplasties.Tranexamic acid, 10 mg/kg body weight, or placebo, was given intravenously just before the operation. Blood loss during the operation and postoperatively into the drains was recorded, as also were blood hemoglobin concentrations. Ultrasound examination I week postoperatively was done to estimate the blood loss due to remaining hematomas.Total (operation + drain) blood loss was 0.76 (95% CI 0.63-0.89) L in the tranexamic acid group as compared to 1.0 (CI 0.81-1.2) L in the placebo group (p = 0.03). The number of blood transfusions during the day of operation was 2 vs. 10 (p = 0.07) and the total number during the hospital stay was 5 vs. 13 (p = 0.2). 1 patient in each group had a pulmonary embolism.