Microcircuitry of Agranular Frontal Cortex: Testing the Generality of the Canonical Cortical Microcircuit
Microcircuitry of Agranular Frontal Cortex: Testing the Generality of the Canonical Cortical Microcircuit
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DOI：
10.1523/jneurosci.5127-13.2014
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发表时间：
2014-04-09
影响因子：
5.3
通讯作者：
Schall, Jeffrey D.
中科院分区：
文献类型：
--
作者：
Godlove, David C.;Maier, Alexander;Schall, Jeffrey D.
我们调查是否额叶区，缺乏颗粒层IV，补充视野，表现出的层状电路的功能类似于在初级感觉区观察到的。我们报告，第一次，视觉诱发的局部场电位（LFPs）和尖峰活动记录同时在所有层的无颗粒额叶皮层使用线性电极阵列。我们计算电流源密度的LFPs和比较的层状组织的不断发展的汇的报告中的感觉区。同时，短暂的突触电流汇首先出现在第三层和第五层，然后更长时间的电流汇在I/II和VI层。我们还发现，没有变化的单或多单位的视觉反应潜伏期跨层，和假定的锥体神经元和中间神经元显示类似的反应潜伏期。许多单位表现出明显的放电抑制，是最强的相对于深层浅层。最大放电抑制也发生在浅层比深层。这些结果进行了讨论的背景下，最初制定的典型的皮层微电路模型来描述早期的感觉皮层。这些数据表明，无颗粒皮质在某些方面类似于感觉区，但皮质微回路以非平凡的方式被修改。
We investigated whether a frontal area that lacks granular layer IV, supplementary eye field, exhibits features of laminar circuitry similar to those observed in primary sensory areas. We report, for the first time, visually evoked local field potentials (LFPs) and spiking activity recorded simultaneously across all layers of agranular frontal cortex using linear electrode arrays. We calculated current source density from the LFPs and compared the laminar organization of evolving sinks to those reported in sensory areas. Simultaneous, transient synaptic current sinks appeared first in layers III and V followed by more prolonged current sinks in layers I/II and VI. We also found no variation of single-or multi-unit visual response latency across layers, and putative pyramidal neurons and interneurons displayed similar response latencies. Many units exhibited pronounced discharge suppression that was strongest in superficial relative to deep layers. Maximum discharge suppression also occurred later in superficial than in deep layers. These results are discussed in the context of the canonical cortical microcircuit model originally formulated to describe early sensory cortex. The data indicate that agranular cortex resembles sensory areas in certain respects, but the cortical microcircuit is modified in nontrivial ways.