Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma
Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma
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DOI：
10.1038/sj.onc.1202416
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发表时间：
1999-02-04
期刊：
影响因子：
8
通讯作者：
Rangnekar, VM
中科院分区：
文献类型：
--
作者：
Cook, J;Krishnan, S;Rangnekar, VM
Par-4 是一种广泛表达的亮氨酸拉链蛋白，可对外源性损伤诱导细胞凋亡敏感。由于促进细胞凋亡的基因表达在肿瘤发生过程中可能会下调，因此我们试图检测人类肿瘤中Par-4的表达，我们在此提供证据表明，相对于正常肾小管细胞，人肾细胞癌标本中Par-4蛋白水平严重降低。肾细胞癌细胞系中Par-4蛋白水平的补充赋予了对细胞凋亡的敏感性。因为细胞凋亡可能作为针对恶性转化或进展的防御机制，所以Par-4表达的降低可能有助于肾细胞癌的病理生理学。
Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors, We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells, Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis, Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.