Two Artificial Tears Outbreak-Associated Cases of Extensively Drug-Resistant Pseudomonas aeruginosa Detected Through Whole Genome Sequencing-Based Surveillance.
Two Artificial Tears Outbreak-Associated Cases of Extensively Drug-Resistant Pseudomonas aeruginosa Detected Through Whole Genome Sequencing-Based Surveillance.
复制标题
通过基于全基因组测序的监测检测到两例与人工泪液爆发相关的广泛耐药铜绿假单胞菌病例。
DOI：
10.1093/infdis/jiad318
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
VanTyne,Daria
中科院分区：
文献类型：
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作者：
Sundermann,AlexanderJ;RangacharSrinivasa,Vatsala;Mills,EmmaG;Griffith,MarissaP;Waggle,KadyD;Ayres,AshleyM;Pless,Lora;Snyder,GrahamM;Harrison,LeeH;VanTyne,Daria
我们描述了2例广泛耐药铜绿假单胞菌感染引起的菌株的公共卫生问题，因为它是最近与全国范围内爆发的污染人工泪液。这两例病例都是通过医院相关传播增强检测系统（EDS-HAT）的基因组数据库审查检测到的，该系统是一个基于基因组测序的常规监测计划。我们从我们中心的分离株中获得了暴发菌株的高质量参考基因组，并检查了编码blaVIM-80和blaGES-9碳青霉烯酶的移动的元件。我们使用公开的铜绿假单胞菌基因组来探索爆发菌株的遗传相关性和抗菌素耐药基因。
We describe 2 cases of extensively drug-resistantPseudomonas aeruginosainfection caused by a strain of public health concern, as it was recently associated with a nationwide outbreak of contaminated artificial tears. Both cases were detected through database review of genomes in the Enhanced Detection System for Hospital-Associated Transmission (EDS-HAT), a routine genome sequencing–based surveillance program. We generated a high-quality reference genome for the outbreak strain from an isolate from our center and examined the mobile elements encodingblaVIM-80andblaGES-9carbapenemases. We used publicly availablePseudomonas aeruginosagenomes to explore the genetic relatedness and antimicrobial resistance genes of the outbreak strain.