The French Pregnancy Cohort: Medication use during pregnancy in the French population
The French Pregnancy Cohort: Medication use during pregnancy in the French population
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DOI：
10.1371/journal.pone.0219095
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发表时间：
2019-07-17
期刊：
影响因子：
3.7
通讯作者：
Schott, Anne-Marie
中科院分区：
文献类型：
--
作者：
Berard, Anick;Abbas-Chorfa, Fatima;Schott, Anne-Marie
目的我们使用法国妊娠队列 (FPC) 描述了法国人群怀孕期间的药物使用情况。方法 FPC 是通过对法国受益人一般受益者 (EGB) 中的所有孕妇进行抽样而建立的，该样本是法国健康保险覆盖人群的 1/97 的代表性样本。 EGB 包含有关受益人的社会人口统计和医疗特征的匿名信息，以及他们所接受的医疗保健服务，例如诊断和程序代码以及已报销药物的数据； EGB 还包括法国所有公立和私立医疗机构的住院数据。每份填写的处方记录包含药品品牌和通用名称、处方日期和配药日期、配药数量、给药方式、处方持续时间、剂量和处方医师专业等信息。 FPC 包含 EGB 中所有女性怀孕的数据（2010-2013 年）。 FPC 的输入日期是怀孕的第一天，无论怀孕结果如何（自然流产或计划流产（有或没有医疗原因）、分娩），并且在怀孕前一年期间回顾性收集妇女数据，在怀孕期间前瞻性收集妇女数据，直至分娩后一年。比较怀孕前、怀孕期间和怀孕后处方药物的使用率；还在三个月之间进行了比较。描述了妊娠结局，包括自发流产和计划流产、活产和死产。结果 FPC 包含 36,065 例妊娠的数据。其中，分娩 27,253 例（75.6%），其中死产 201 例（0.7%）。自然流产总数为 6,718 例（18.6%），计划流产 2,094 例（5.8%）。孕前、孕中、孕后填充药物使用率分别为91.1%、89.9%和95.6%。尽管一旦确诊怀孕，使用比例就出现统计学上的显着下降（妊娠前三个月的暴露率为 76.4%，而怀孕前一年的暴露率为 91.1%（p
PurposeWe described the medication use during pregnancy in the French population using the French Pregnancy Cohort (FPC).MethodsThe FPC was built with the sampling of all pregnant women included in the French Echantillon generaliste des beneficiaires (EGB), which is a 1/97th representative sample of the population covered by the French health insurance. The EGB includes anonymized information on the socio-demographic and medical characteristics of beneficiaries, and the health care services they have received such as diagnoses and procedure codes as well as data on filled reimbursed medication; EGB also includes data on hospital stays in all public and private French health facilities. Each filled prescription record contains information on drug brand and generic names, date of prescription and date of dispensing, quantity dispensed, mode of administration, duration of prescription, dosage, and prescribing physician specialty. FPC includes data on all pregnancies of women in the EGB (2010-2013). Date of entry in the FPC is the first day of pregnancy regardless of pregnancy outcome (spontaneous abortions or planned abortions (with or without medical reasons), deliveries), and data on women are collected retrospectively for a period of one year before pregnancy, and prospectively during pregnancy, and up to one year after delivery. The prevalence of prescribed medications before, during and after pregnancy was compared; comparison was also done between trimesters. Pregnancy outcomes are described and include spontaneous and planned abortions, livebirths, and stillbirths.ResultsFPC includes data on 36,065 pregnancies. Among them, 27,253 (75.6%) resulted in a delivery including 201 stillbirths (0.7%). The total number of spontaneous abortions was 6,718 (18.6%), and planned abortions 2,094 (5.8%). The prevalence of filled medication use was 91.1%, 89.9%, and 95.6% before, during and after pregnancy, respectively. Although there was a statistically significant decrease in the proportion of use once the pregnancy was diagnosed (first trimester exposure, 76.4% vs. exposure in the year prior to pregnancy, 91.1% (p