Changes in biomarkers of bone resorption over the first six months after pediatric hematopoietic cell transplantation.
Changes in biomarkers of bone resorption over the first six months after pediatric hematopoietic cell transplantation.
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DOI：
10.1111/j.1399-3046.2012.01780.x
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发表时间：
2012-12
影响因子：
1.3
通讯作者：
Petryk A
中科院分区：
文献类型：
--
作者：
Polgreen LE;Rudser K;Deyo M;Smith A;Baker KS;Petryk A
在儿童和成人中，在造血细胞移植（HCT）后的前六个月内观察到骨丢失。虽然有一些证据表明HCT后儿童的骨形成可能减少，但目前尚不清楚骨吸收是否增加。这项前瞻性研究的目的是评价儿童HCT后前6个月内骨吸收标志物的变化。26名年龄为10.9 ± 3.4岁的受试者（8名女性）在HCT前入组研究。用尿脱氧吡啶啉（DPD）、吡啶啉（PYD）及血浆N端肽（NTX）、C端肽（CTX）测定骨吸收。17名完成第+30天访视和第+100天或第+180天访视的参与者被纳入分析。DPD在第+30天和第+100天之间增加（平均变化11.3 nmol/nmol肌酐; p = 0.012），在第+30天和第+180天之间增加（13.7 nmol/nmol肌酐; p = 0.036）。PYD在+30天至+100天之间增加（32 nmBCE/L; p = 0.019）。CTX在基线和第+100天之间增加（5.9 μ g/L; p = 0.012）。NTX水平的变化没有统计学意义。这项研究表明，HCT后儿童的骨吸收标志物增加，表明骨吸收增加可能是儿科HCT后骨丢失的病理生理学的一个促成因素。
Bone loss has been observed within the first six months after hematopoietic cell transplantation (HCT) in both children and adults. While there is some evidence that bone formation may be reduced in children after HCT, it is currently unknown if bone resorption is increased. The objective of this prospective study was to evaluate changes in markers of bone resorption over the first six months after pediatric HCT. Twenty-six participants (8 females) age 10.9±3.4 years entered the study prior to HCT. Bone resorption was measured by urine deoxypyridinoline (DPD) and pyridinoline (PYD), and by plasma N-telopeptide (NTX) and C-telopeptide (CTX). Seventeen participants who completed day +30 visit and either day +100 or +180 visits were included in the analysis. DPD increased between days +30 and +100 (mean change 11.3 nmol/nmol creatinine; p=0.012) and between days +30 and +180 (13.7 nmol/nmol creatinine; p=0.036). PYD increased between days +30 and +100 (32 nmBCE/L; p=0.019). CTX increased between baseline and day +100 (5.9 μg/L; p=0.012). Changes in NTX levels were not statistically significant. This study shows that markers of bone resorption increase in children after HCT, suggesting that increased resorption may be a contributing factor to the pathophysiology of bone loss after pediatric HCT.
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影响因子：
6.2
作者：
Ebeling, PR;Thomas, DM;Grigg, AP
通讯作者：
Grigg, AP
影响因子：
4.8
作者：
Kaste, SC;Shidler, TJ;Hale, GA
通讯作者：
Hale, GA
DOI：
10.1053/bbmt.2001.v7.pm11400947
发表时间：
2001-01-01
影响因子：
4.3
作者：
Stern, JM;Sullivan, KM;Sherrard, DF
通讯作者：
Sherrard, DF
影响因子：
4.3
作者：
Carpenter, Paul A.;Hoffmeister, Paul;Sanders, Jean E.
通讯作者：
Sanders, Jean E.
DOI：
10.1359/jbmr.060601
发表时间：
2006-09
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Clark EM;Ness AR;Bishop NJ;Tobias JH
通讯作者：
Tobias JH