Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies.
Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies.
复制标题
多发性脑梗塞和痴呆与抗心磷脂抗体相关。
作者：
Coull,BM;Bourdette,DN;GoodnightJr,SH;Briley,DP;Hart,R
在系统性红斑狼疮和其他疾病患者的血清中发现了对负电荷磷脂（包括心磷脂）的抗体。我们报告了4例与抗心磷脂抗体相关的脑梗死和痴呆患者。这些患者没有狼疮抗凝血剂或系统性红斑狼疮。在没有系统性血管炎或炎症的多发性脑梗死患者中出现抗心磷脂抗体表明，这种关联可能比以前认识到的更常见。在不明原因脑梗死患者中检测抗心磷脂抗体的存在可能是有用的。
Antibodies to negatively charged phospholipids including cardiolipin have been recognized in the sera of patients with systemic lupus erythematosus and other disorders. We report 4 patients who experienced cerebral infarctions and dementia in association with anticardiolipin antibodies. These patients did not have the characteristic lupus anticoagulant or systemic lupus erythematosus. The occurrence of anticardiolipin antibodies in patients with multiple cerebral infarctions who do not have evidence of a systemic vasculitis or inflammatory condition suggests that this association may be more common than previously recognized. It may be useful to test for the presence of anticardiolipin antibodies in patients who have unexplained cerebral infarctions.