Longitudinal serum concentrations of placental growth factor: Evidence for abnormal placental angiogenesis in pathologic pregnancies
Longitudinal serum concentrations of placental growth factor: Evidence for abnormal placental angiogenesis in pathologic pregnancies
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DOI：
10.1067/mob.2003.111
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发表时间：
2003-01-01
影响因子：
9.8
通讯作者：
North, RA
中科院分区：
文献类型：
--
作者：
Taylor, RN;Grimwood, J;North, RA
目的：复杂妊娠表现为蜕膜和胎盘绒毛血管的异常。我们检测了正常妊娠和合并孤立的特发性小胎龄（SGA）新生儿、单独子痫前期、或在临床发病时和临床体征出现之前伴有SGA新生儿的子痫前期孕妇血管内皮生长因子和胎盘生长因子的浓度。研究设计：采用酶联免疫吸附法在横断面和纵向队列中检测未生育孕妇的血清血管内皮生长因子和胎盘生长因子。结果分别通过Wilcoxon检验和混合模型方法进行比较。结果：在横断面研究中，早在妊娠15 ~ 19周，异常妊娠伴SGA新生儿的血清胎盘生长因子就较对照组（SGA新生儿，18例[P = .04]；子痫前期，20例；或子痫前期伴小胎龄新生儿，11例[P = .0001]）降低。血管内皮生长因子
OBJECTIVE: Complicated pregnancies demonstrate abnormal decidual and placental villous vasculature. We examined maternal concentrations of vascular endothelial growth factor and placental growth factor in normal pregnancies and in pregnancies that were complicated by isolated idiopathic small-for-gestational-age (SGA) newborn infants, preeclampsia alone, or preeclampsia with SGA newborn infants at the time of clinical disease and before the onset of clinical signs.STUDY DESIGN: Serum vascular endothelial growth factor and placental growth factor were measured by enzyme-linked immunosorbent assay in cross-sectional and longitudinal cohorts of pregnant-nulliparous women. The results were compared by Wilcoxon tests or a mixed-models method, respectively.RESULTS: In the cross-sectional study, serum placental growth factor was reduced in abnormal pregnancy relative to control subjects (SGA newborn infants, 18 [P = .04]; preeclampsia, 20; or preeclampsia with small-for-gestational-age newborn infants, 11 [P = .0001]) as early as 15 to 19 weeks of gestation in preeclampsia with SGA newborn infants. Vascular endothelial growth factor was