Metabolic Inflammation-A Role for Hepatic Inflammatory Pathways as Drivers of Comorbidities in Nonalcoholic Fatty Liver Disease?
Metabolic Inflammation-A Role for Hepatic Inflammatory Pathways as Drivers of Comorbidities in Nonalcoholic Fatty Liver Disease?
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DOI：
10.1053/j.gastro.2020.02.020
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发表时间：
2020-05-01
期刊：
影响因子：
29.4
通讯作者：
Schattenberg, Joern M.
中科院分区：
文献类型：
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作者：
Gehrke, Nadine;Schattenberg, Joern M.
非酒精性脂肪性肝病(NAFLD)是一个全球性且日益严重的健康问题。新的证据表明，代谢性炎症是脂肪肝的一个关键过程，导致多器官并发症。受NAFLD影响的主要肝外合并症是2型糖尿病、心血管疾病和神经认知功能受损。重要的是，非酒精性脂肪性肝炎和进展性肝纤维化的存在增加了NAFLD全身性共病的风险。尽管肝脏和其他器官之间的确切性质尚未完全阐明，但越来越多的证据表明，代谢和炎症-部分来自脂肪肝-是推动细胞功能障碍、细胞死亡和身体各种组织内有害重塑的引擎。本综述描述了NAFLD与2型糖尿病、心血管疾病和神经认知功能下降之间的联系的几种炎症途径和介质。
Nonalcoholic fatty liver disease (NAFLD) is a global and growing health concern. Emerging evidence points toward metabolic inflammation as a key process in the fatty liver that contributes to multiorgan morbidity. Key extrahepatic comorbidities that are influenced by NAFLD are type 2 diabetes, cardiovascular disease, and impaired neurocognitive function. Importantly, the presence of nonalcoholic steatohepatitis and advanced hepatic fibrosis increase the risk for systemic comorbidity in NAFLD. Although the precise nature of the crosstalk between the liver and other organs has not yet been fully elucidated, there is emerging evidence that metabolic inflammation—in part, emanating from the fatty liver—is the engine that drives cellular dysfunction, cell death, and deleterious remodeling within various body tissues. This review describes several inflammatory pathways and mediators that have been implicated as links between NAFLD and type 2 diabetes, cardiovascular disease, and neurocognitive decline.