Submillimeter isotropic resolution carotid wall MRI with swallowing compensation: Imaging results and semiautomated wall morphometry
Submillimeter isotropic resolution carotid wall MRI with swallowing compensation: Imaging results and semiautomated wall morphometry
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DOI：
10.1002/jmri.20849
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发表时间：
2007-04-01
影响因子：
4.4
通讯作者：
Li, Debiao
中科院分区：
文献类型：
--
作者：
Koktzoglou, Ioannis;Li, Debiao
目的：评估吞咽补偿、三维（3D）扩散准备分段稳态自由进动（3D Nav-D-SSFP）技术用于具有0.6 mm各向同性空间分辨率的颈动脉壁MRI，及其用于半自动颈动脉壁形态测量的实用性。对7名健康志愿者（N = 14）的颈动脉进行三维Nav-D-SSFP和黑血T2加权（T2 w）二维（2D）快速自旋回波（FSE）成像。颈动脉壁腔对比度噪声比（CNR）测量与两个序列。结果：经体素体积和切片数调整后，3D Nav-D-SSFP与2D T2 w FSE相比，单位时间CNR提高近6倍（P < 0.001）。在3D Nav-D-SSFP图像上手动和半自动测量颈动脉WA和LA高度相关（组内相关系数（ICC）分别为0.961和0.996; P < 0.001）。3D Nav-D-SSFP是一种省时、吞咽补偿、黑血技术，适用于颈动脉WA和LA的半自动测量，与手动测量结果吻合良好。
Purpose: To assess a swallowing-compensated, three-dimensional (3D) diffusion-prepared segmented steady-state free precession (3D Nav-D-SSFP) technique for carotid wall MRI with 0.6-mm isotropic spatial resolution, and its utility for semiautomated carotid wall morphometry.Materials and Methods: The carotid arteries of seven healthy volunteers (N = 14) were imaged with 3D Nav-D-SSFP and black-blood T2-weighted (T2w) two-dimensional (2D) fast spin-echo (FSE). Carotid wall-lumen contrast-to-noise ratio (CNR) was measured with both sequences. Measurement of carotid wall area (WA) and lumen area (LA) made in a semiautomated manner off of the 3D Nav-D-SSFP images were compared to those made manually.Results: Adjusted for voxel volume and number of slices, a near six-fold improvement in CNR per unit time was achieved with 3D Nav-D-SSFP relative to 2D T2w FSE (P < 0.001). Manual and semiautomated measurements of carotid WA and LA on the 3D Nav-D-SSFP images were highly correlated (intraclass correlation coefficient (ICC) 0.961 and 0.996, respectively; P < 0.001).Conclusion: 3D Nav-D-SSFP is a time-efficient, swallowing-compensated, black-blood technique that lends itself for semiautomated measurements of carotid WA and LA that are in good agreement with manual measurements.