"mTOR Signaling Pathway": A Potential Target of Curcumin in the Treatment of Spinal Cord Injury.
"mTOR Signaling Pathway": A Potential Target of Curcumin in the Treatment of Spinal Cord Injury.
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DOI：
10.1155/2017/1634801
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发表时间：
2017
影响因子：
--
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Lin J;Huo X;Liu X
本文综述了姜黄素通过调节mTOR信号通路治疗脊髓损伤（spinal cord injury，SCI）的可能性，为姜黄素成为一种有前途的SCI治疗药物提供了有力的支持。姜黄素是一种多功能靶向治疗药物，在许多疾病的治疗中调节mTOR信号通路。已有研究表明，mTOR信号通路参与了轴突再生和自噬过程，在预后中起着重要作用。本文综述了姜黄素抑制该通路的激活，改善轴突再生微环境的可能机制，为合理诱导自噬提供了新的途径。
The purpose of this review is to discuss the possibility of the treatment of spinal cord injury (SCI) with curcumin via regulating the mTOR signaling pathway, which may provide another strong support for curcumin to be a promising medicine applied to the treatment of SCI. Curcumin is termed as a multifunctional targeting therapy drug that regulates the mTOR signaling pathway in the treatment of numerous diseases. Previous research has already revealed that mTOR signaling pathway plays a vital role in prognosis, which involves the axon regeneration and autophagy. This review discusses a potential mechanism that curcumin suppresses the activation of this pathway and ameliorates the microenvironment of axons regeneration which would provide a new way that induces autophagy appropriately.