Causal Associations Between Blood Lipids and COVID-19 Risk: A Two-Sample Mendelian Randomization Study
Causal Associations Between Blood Lipids and COVID-19 Risk: A Two-Sample Mendelian Randomization Study
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血脂与 COVID-19 风险之间的因果关系：双样本孟德尔随机研究
DOI：
10.1161/atvbaha.121.316324
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发表时间：
2021-09
影响因子：
8.7
通讯作者：
Yang Tie-Lin
中科院分区：
文献类型：
--
作者：
Zhang Kun;Dong Shan-Shan;Guo Yan;Tang Shi-Hao;Wu Hao;Yao Shi;Wang Peng-Fe;Xue Han-Zhong;Huang Wei;Ding Jian;Yang Tie-Lin
补充数字内容可在文本中找到。目的：冠状病毒病2019 （COVID-19）是由严重急性呼吸综合征冠状病毒2引起的全球性大流行疾病。据报道，血脂异常与COVID-19相关，血脂水平，包括总胆固醇、HDL-C（高密度脂蛋白胆固醇）和LDL-C（低密度脂蛋白胆固醇）水平与疾病严重程度显著相关。然而，血脂对COVID-19的影响尚不清楚。方法和结果：我们采用两样本孟德尔随机化（MR）分析，探讨血脂与COVID-19易感性和严重程度的因果关系。使用来自英国生物银行（1221例病例和4117例对照）的结果数据，我们观察到Bonferroni校正后，血脂异常（比值比[OR]， 1.27 [95% CI, 1.08-1.49]， P=3.18×10−3）、总胆固醇（比值比[OR]， 1.19 [95% CI, 1.07-1.32]， P=8.54×10−4）和载脂蛋白B（载脂蛋白B； OR, 1.18 [95% CI, 1.07-1.29]， P=1.01×10−3）对COVID-19易感性的潜在积极因果影响。此外，总胆固醇（OR, 1.01 [95% CI, 1.00-1.02]， P=2.29×10−2）和载脂蛋白ob （OR, 1.01 [95% CI, 1.00-1.02]， P=2.22×10−2）对COVID-19易感性的影响也通过宿主遗传计划（14 134例和1 284 876例对照）的结果数据进行了鉴定。结论：总之，我们发现较高的总胆固醇和载脂蛋白ob水平可能会增加COVID-19感染的风险。
Supplemental Digital Content is available in the text. Objective: Coronavirus disease 2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus 2. It has been reported that dyslipidemia is correlated with COVID-19, and blood lipids levels, including total cholesterol, HDL-C (high-density lipoprotein cholesterol), and LDL-C (low-density lipoprotein cholesterol) levels, were significantly associated with disease severity. However, the causalities of blood lipids on COVID-19 are not clear. Approach and Results: We performed 2-sample Mendelian randomization (MR) analyses to explore the causal effects of blood lipids on COVID-19 susceptibility and severity. Using the outcome data from the UK Biobank (1221 cases and 4117 controls), we observed potential positive causal effects of dyslipidemia (odds ratio [OR], 1.27 [95% CI, 1.08–1.49], P=3.18×10−3), total cholesterol (OR, 1.19 [95% CI, 1.07–1.32], P=8.54×10−4), and ApoB (apolipoprotein B; OR, 1.18 [95% CI, 1.07–1.29], P=1.01×10−3) on COVID-19 susceptibility after Bonferroni correction. In addition, the effects of total cholesterol (OR, 1.01 [95% CI, 1.00–1.02], P=2.29×10−2) and ApoB (OR, 1.01 [95% CI, 1.00–1.02], P=2.22×10−2) on COVID-19 susceptibility were also identified using outcome data from the host genetics initiative (14 134 cases and 1 284 876 controls). Conclusions: In conclusion, we found that higher total cholesterol and ApoB levels might increase the risk of COVID-19 infection.
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DOI：
10.3760/cma.j.cn112338-20200427-00659
发表时间：
2020-12
影响因子：
--
作者：
Chaolin Huang;Ye-ming Wang;Xing-wang Li;L. Ren;Jianping Zhao;Y. Hu;Li Zhang;Guohui Fan;
通讯作者：
Chaolin Huang;Ye-ming Wang;Xing-wang Li;L. Ren;Jianping Zhao;Y. Hu;Li Zhang;Guohui Fan;
影响因子：
7.7
作者：
Bowden J;Spiller W;Del Greco M F;Sheehan N;Thompson J;Minelli C;Davey Smith G
通讯作者：
Davey Smith G
脂筏介导的附着在冠状病毒传染性支气管炎病毒Beaudette菌株感染培养细胞中的重要作用
影响因子：
3.7
作者：
Guo H;Huang M;Yuan Q;Wei Y;Gao Y;Mao L;Gu L;Tan YW;Zhong Y;Liu D;Sun S
通讯作者：
Sun S
影响因子：
2
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan N;Thompson J
通讯作者：
Thompson J
影响因子：
7.7
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan NA;Thompson JR
通讯作者：
Thompson JR