Ultrafiltration coefficient of isolated glomeruli of rats aged 4 days to maturation.
Ultrafiltration coefficient of isolated glomeruli of rats aged 4 days to maturation.
复制标题
4天龄至成熟大鼠离体肾小球的超滤系数。
DOI：
10.1038/ki.1985.219
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发表时间：
1985
影响因子：
19.6
通讯作者：
Richardson,WP
中科院分区：
文献类型：
--
作者：
Savin,VJ;Beason-Griffin,C;Richardson,WP
Ultrafiltration coefficient of isolated glomeruli of rats aged 4 days to maturation. In the developing rat, RBF and GFR increase in parallel. We have calculated filtration coefficient (Kf) and hydraulic conductivity (Lp) of the glomerular capillary using glomeruli isolated from Munich-Wistar rats aged 4 days to adult. Lp derived as the quotient of Kfand total basement membrane area (LpS) may represent a minimum estimate, while the quotient of Kfand the peripheral basement membrane area (LpP) may more accurately represent the value that is operative in vivo. Rats in Group 1 (age 4 to 9 days) had an average glomerular diameter of 87 ± 3 µm, Kfof 1.7 ± 0.3 nl/min · mm Hg and LpSand LpP, 1.9 ± 0.2 and 4.4 ± 0.6 µl/min · mm Hg · cm2, respectively. Glomerular diameter and Kfwere not significantly increased in rats of Group 2 (22 to 36 days), but LpSand LpPdiminished to 1.5 ± 0.1 and 2.6 ± 0.2 µl/min · mm Hg · cm2because of an increase in basement membrane surface density. In older rats of Groups 3 (69 to 84 days) and 4 (about 120 days, wt 205 ± 4 g), glomerular diameter and Kfincreased progressively. Kfand diameter were greater in deep than in superficial glomeruli of Group 4. In superficial glomeruli of Group 4, LpSaveraged 1.1 ± 0.1 and LpP2.0 ± 0.1 µl/min · mm Hg · cm2, and were significantly lower than the values for Group 2 but not different from those of deep glomeruli of Group 4. Relative erythrocyte ejection increased with increasing glomerular diameter, indicating decreasing capillary resistance. Our observations are consistent with the previous reports that renal perfusion, Kf, and filtration rate increase in parallel, but do not support the hypothesis that glomerular capillary hydraulic conductivity increases as the filtration barrier matures.
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