Gender and Age Differences in Growth Factor Concentrations From Platelet-Rich Plasma in Adults
Gender and Age Differences in Growth Factor Concentrations From Platelet-Rich Plasma in Adults
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DOI：
10.7205/milmed-d-13-00336
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发表时间：
2014-07-01
影响因子：
1.2
通讯作者：
Bojescul, John A.
中科院分区：
文献类型：
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作者：
Evanson, J. Richard;Guyton, M. Kelly;Bojescul, John A.
使用富含血小板的血浆（PRP）来促进骨科相关损伤的愈合已变得越来越流行；然而，临床益处并不一致。差异可能是由于正常人群中生长因子 (GF) 水平的变化造成的。本研究的目的是确定健康人群 (N = 102) 中活化的 PRP 制剂中存在的 GF 水平是否因性别和年龄 (25 岁) 的不同而不同。分析的所有 GF（表皮生长因子 [EGF]、肝细胞生长因子 [HGF]、胰岛素生长因子-1 [IGF-1]、血小板衍生生长因子-AB [PDGF-AB]、血小板衍生生长因子-BB [PDGF-BB]、转化生长因子 beta-1 [TGF beta-1] 和血管内皮生长因子）在女性和女性中均具有较高水平。
The use of platelet-rich plasma (PRP) to facilitate healing of orthopedic-related injuries has gained popularity; however, the clinical benefits are not consistent. Differences may result from variations in growth factor (GF) levels in normal populations. The purpose of this study was to determine if GF levels present in activated PRP preparations differed by gender and age (25 years) in a healthy population (N = 102). All GFs analyzed (epidermal growth factor [EGF], hepatocyte growth factor [HGF], insulin growth factor-1 [IGF-1], platelet-derived growth factor-AB [PDGF-AB], platelet-derived growth factor-BB [PDGF-BB], transforming growth factor beta-1 [TGF beta-1], and vascular endothelial growth factor) had higher levels for females and for those