Synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidine derivatives by proline-catalyzed multicomponent reaction
Synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidine derivatives by proline-catalyzed multicomponent reaction
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脯氨酸催化多组分反应合成稠合吡咯并[3,4-d]四氢嘧啶衍生物
DOI：
10.1016/j.tet.2014.04.075
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发表时间：
2014-07-22
期刊：
影响因子：
2.1
通讯作者：
Liu, Shu-Wen
中科院分区：
文献类型：
--
作者：
Chen, Zhi-Peng;Wang, Hai-Bo;Liu, Shu-Wen
以N-甲基-α-芳基（烷基）氨基马来酰亚胺、胺和醛为反应物，开发了脯氨酸催化的多组分反应（MCR），合成了具有不同取代模式的稠合吡咯并[3，4-d]四氢嘧啶7和9。催化剂和反应物配比对反应有显著影响，并提出了合理的反应机理。(C)2014爱思唯尔有限公司版权所有。
Novel proline-catalyzed multicomponent reactions (MCRs) for the synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidines 7 and 9 with different substituted patterns have been developed, which provide rapid access to a library of compounds 7 and 9 in medium to excellent yields, by using N-methyl-alpha-aryl(alkyl)aminomaleimides, amines, and aldehydes as reactants. The catalyst and the ratio of reactants were found to have significant impact on these reactions, and a reasonable mechanism was also proposed. (C) 2014 Elsevier Ltd. All rights reserved.