MORPHINE-INDUCED POTENTIATION OF BRAIN-STIMULATION REWARD IS ENHANCED BY MK-801
MORPHINE-INDUCED POTENTIATION OF BRAIN-STIMULATION REWARD IS ENHANCED BY MK-801
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DOI：
10.1016/0006-8993(93)90177-o
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发表时间：
1993-08-27
期刊：
影响因子：
2.9
通讯作者：
WISE, RA
中科院分区：
文献类型：
--
作者：
CARLEZON, WA;WISE, RA
吗啡（2.5 mg/kg，i. p.）和MK-801（0.05 mg/kg，腹腔注射）每一个都增强了内侧前脑束的电刺激的有益影响，导致将响应率与刺激频率相关的功能的小但可靠的平行的反向移位。MK-801和吗啡联合给药引起了功能的深刻变化。这种效应不是由于对任何一种药物的致敏作用，这表明阿片能功能的破坏可以增强阿片类药物的奖励作用。
Morphine (2.5 mg/kg, i.p.) and MK-801 (0.05 mg/kg, i.p.) each enhanced the rewarding impact of electrical stimulation of the medial forebrain bundle, causing small but reliable parallel leftward shifts of the functions relating response rate to stimulation frequency. Administration of MK-801 and morphine together caused a profound leftward shift in the functions. This effect was not due to sensitization to either drug, and suggests that disruption of glutamatergic function can potentiate the rewarding impact of opiates.