The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor
The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor
复制标题
DOI：
10.1016/s0092-8674(00)80134-8
复制
发表时间：
1996-08-23
期刊：
影响因子：
64.5
通讯作者：
Ferguson, EL
中科院分区：
文献类型：
--
作者：
Holley, SA;Neul, JL;Ferguson, EL
头蛋白在非洲爪蟾胚胎的Spemann组织者区域中表达，并且可以促进中胚层内的背细胞命运和上覆的外胚层内的神经发育。在这里，我们表明，noggin促进腹侧果蝇的发展，指定腹侧外胚层和中枢神经系统的所有内源性腹侧特异性合子基因表达的情况下。我们利用组成型活性形式的dpp受体，以证明头蛋白阻断dpp受体激活的dpp信号上游。这些结果表明，在非洲爪蟾的发展过程中的Spemann的组织者的行动的机械基础，并提供进一步的支持，保护背腹图案之间的节肢动物和脊索动物的机制。
noggin is expressed in the Spemann organizer region of the Xenopus embryo and can promote dorsal cell fates within the mesoderm and neural development within the overlying ectoderm. Here, we show that noggin promotes ventral development in Drosophila, specifying ventral ectoderm and CNS in the absence of all endogenous ventral-specific zygotic gene expression. We utilize constitutively active forms of the dpp receptors to demonstrate that noggin blocks dpp signaling upstream of dpp receptor activation. These results suggest a mechanistic basis for the action of Spemann's organizer during Xenopus development and provide further support for the conservation of dorsal-ventral patterning mechanisms between arthropods and chordates.