Itching-related somatosensory evoked potentials
Itching-related somatosensory evoked potentials
复制标题
DOI：
10.1016/j.pain.2008.02.017
复制
发表时间：
2008-09-15
期刊：
影响因子：
7.4
通讯作者：
Kakigi, Ryusuke
中科院分区：
文献类型：
--
作者：
Mochizuki, Hideki;Inui, Kouji;Kakigi, Ryusuke
电诱发瘙痒具有很强的潜力，可用于调查中央处理与瘙痒在高时间分辨率，采用脑磁图，脑电图（EEG），和事件相关的功能磁共振成像。然而，还没有研究是否可以使用这种刺激来测量时间锁定的大脑活动，以及由皮肤的电刺激引起的瘙痒感觉是否与C纤维相关。因此，我们在这项研究中调查了这些问题。当电刺激施加到右手腕和右前臂的皮肤时，引起瘙痒感觉。从5个电极（Fz、FCz、Cz、CPz和Pz）记录EEG活动。当刺激右腕时，体感诱发电位阳性成分（P1）的反应时间（RT）和潜伏期分别为1215 ms和963 ms。当刺激右前臂时，P1的RT和峰潜伏期分别为1013 ms和772 ms。根据RT和P1潜伏期估计的传导速度分别为1.04 m/s和0.92 m/s。此外，当电流强度增加到引起疼痛和触觉的范围时，瘙痒感觉和P1被抑制，这意味着C-和A-纤维之间的相互作用。这些研究结果表明，时间锁定的大脑活动可以使用电诱发瘙痒来测量，并且由电诱发瘙痒引起的瘙痒感觉与C纤维相关。因此，这种方法对于研究瘙痒的中枢处理是有用的。(C)2008年国际疼痛研究协会。Elsevier B. V.出版，保留所有权利。
Electrically evoked itching has the strong potential to be used to investigate the central processing associated with itching at high temporal resolution by employing magnetoencephalography, electroencephalography (EEG), and event-related functional magnetic resonance imaging. However, it has not been investigated whether time-locked brain activity can be measured using this stimulus, and whether the itching sensation induced by electrical stimulation of the skin is associated with C-fibers. Thus, we investigated these problems in this study. Itching sensations were elicited when electrical stimuli were applied to the skin of the right wrist and right forearm. EEG activity was recorded from 5 electrodes (Fz, FCz, Cz, CPz and Pz). When the right wrist was stimulated, the reaction time (RT) and latency of the positive component of somatosensory evoked potentials (P1) were 1215 ms and 963 ms, respectively. When the right forearm was stimulated, the RT and peak latency of the P1 were 1013 ms and 772 ms, respectively. The conduction velocity estimated from the RT and latency of the P1 was 1.04 m/s and 0.92 m/s, respectively. In addition, the itching sensation and P1 were inhibited when the current intensity was increased into the range eliciting pain and touch sensations, implying interaction between C- and A-fibers. These findings demonstrate that time-locked brain activity can be measured using electrically evoked itching and that the itching sensation induced by the electrically evoked itching is associated with C-fibers. Thus, this method is useful for research into the central processing of itching. (C) 2008 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.