Microvascular Vasodilator Plasticity After Acute Exercise.
Microvascular Vasodilator Plasticity After Acute Exercise.
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DOI：
10.1249/jes.0000000000000130
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发表时间：
2018-01
影响因子：
5.7
通讯作者：
Phillips SA
中科院分区：
文献类型：
--
作者：
Robinson AT;Fancher IS;Mahmoud AM;Phillips SA
急性运动或久坐成人的孤立小动脉腔内高压后，内皮依赖性血管舒张功能降低，但定期运动者的小动脉血管舒张功能不降低。锻炼者在小动脉中保留的血管扩张依赖于过氧化氢（H2O2），而静息时的扩张依赖于一氧化氮（NO）。我们假设，当一氧化氮生物利用度降低时，慢性运动引起适应，允许维持血管舒张。
Endothelium-dependent vasodilation is reduced following acute exercise, or following high intraluminal pressure in isolated arterioles from sedentary adults, but not in arterioles from regular exercisers. The preserved vasodilation in arterioles from exercisers is hydrogen peroxide (H2O2)-dependent, whereas resting dilation is nitric oxide (NO)-dependent. We hypothesize chronic exercise elicits adaptations allowing for maintained vasodilation when NO bioavailability is reduced.