INHIBITORY ACTIVITY OF JATROPHA-MULTIFIDA LATEX ON CLASSICAL COMPLEMENT PATHWAY ACTIVITY IN HUMAN-SERUM MEDIATED BY A CALCIUM-BINDING PROANTHOCYANIDIN
INHIBITORY ACTIVITY OF JATROPHA-MULTIFIDA LATEX ON CLASSICAL COMPLEMENT PATHWAY ACTIVITY IN HUMAN-SERUM MEDIATED BY A CALCIUM-BINDING PROANTHOCYANIDIN
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DOI：
10.1016/0378-8741(89)90080-9
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发表时间：
1989-11-01
影响因子：
5.4
通讯作者：
LABADIE, RP
中科院分区：
文献类型：
--
作者：
KOSASI, S;THART, LA;LABADIE, RP
本研究分离并表征了多裂麻风树胶乳中存在的抗补体成分，试图解释胶乳在治疗感染伤口中的传统应用。通过抑制人血清中的经典途径（CP）补体活性，分离出一种聚合物，其特征在于它是一种原花青素。聚合物抑制补体级联的CP激活，而旁路途径（AP）激活对聚合物相对不敏感。这是由于从孵育培养基中选择性消耗Ca2+，而不是Mg2+。
This study isolates and characterizes the anti-complement constituent(s)present in the latex of Jatropha multifida, in an attempt to explain the traditional application of the latex in the treatment of infected wounds. Guided by the inhibition of classical pathway (CP) complement activity in human serum, a polymer was isolated which could be characterized as a proanthocyanidin. The polymer inhibits CP activation of the complement cascade, while alternative pathway (AP) activation is relatively insensitive to the polymer. This is due to the selective depletion of Ca2+, but not Mg2+, from the incubation medium.