Cognitive assessment in Alzheimer's disease: cross-sectional and longitudinal perspectives.
Cognitive assessment in Alzheimer's disease: cross-sectional and longitudinal perspectives.
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阿尔茨海默病的认知评估：横断面和纵向视角。
DOI：
10.1017/s0317167100037033
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Stebbins,GT
中科院分区：
文献类型：
--
作者：
Kaszniak,AW;Wilson,RS;Fox,JH;Stebbins,GT
本文描述了一项纵向研究的选择结果，62轻度至中度阿尔茨海默病（AD）患者，与60个年龄匹配的健康对照。最初的神经学、放射学、精神病学、实验室和认知检查需要两整天，然后每年进行一次为期一天的检查。在全部原始样本中，31名AD患者和39名对照者实际上可以进行三次年度检查。认知检查数据证实了记忆和语言测量的横截面（组区分）有效性，并显示了AD样本的预期纵向恶化，对照组在三年内保持一致的表现。然而，在初始检查时显示最大组间差异的那些指标并不是跟踪患者随时间恶化的最佳指标。这些结果对认知评估措施的选择的影响进行了讨论。
This paper describes select results of a longitudinal study of 62 mild to moderate Alzheimer's disease (AD) patients, in comparison to 60 age-matched healthy controls. Initial neurologic, radiologic, psychiatric, laboratory and cognitive examinations, required two full days, followed by one-day examinations at annual intervals. Of the total original sample, 31 AD patients and 39 controls could actually be followed for three annual examinations. Cognitive examination data confirmed cross-sectional (group discriminative) validity of memory and language measures, and showed the expected longitudinal deterioration in the AD sample, with controls maintaining consistent performance over the three years. However, those measures showing largest group differences at initial examination were not the best for tracking patient deterioration over time. Implications of these results for the selection of cognitive assessment measures are discussed.