Formulations for intermittent release of parathyroid hormone (1-34) and local enhancement of osteoblast activities.
Formulations for intermittent release of parathyroid hormone (1-34) and local enhancement of osteoblast activities.
复制标题
用于间歇性释放甲状旁腺激素 (1-34) 和局部增强成骨细胞活性的制剂。
DOI：
10.1080/10837450802282488
复制
发表时间：
2008
影响因子：
3.4
通讯作者：
Puleo,DA
中科院分区：
文献类型：
--
作者：
Jeon,JH;Puleo,DA
这些研究的目的是开发简单的可植入装置，间歇释放PTH（1-34），从而可用于局部刺激骨形成。该制剂基于邻苯二甲酸乙酸纤维素和Pluronic F-127的缔合聚合物体系。间歇装置的释放曲线显示五个离散峰，而持续装置表现出零级动力学。与持续暴露相比，用PTH（1-34）间歇处理的细胞的成骨细胞活性更大。这些以间歇方式递送PTH（1-34）的控释装置可用于影响局部区域中的成骨细胞活性。
The objective of these studies was to develop simple, implantable devices that intermittently release PTH(1-34) and thus could be used for locally stimulating bone formation. The formulations were based on the association polymer system of cellulose acetate phthalate and Pluronic F-127. Release profiles for intermittent devices showed five discrete peaks, whereas sustained devices exhibited zero-order kinetics. Osteoblastic activity was greater for cells intermittently treated with PTH(1-34) compared to sustained exposure. These controlled release devices delivering PTH(1-34) in an intermittent manner may be useful for affecting osteoblast activities in a localized area.