Association between 6-n-propylthiouracil (PROP) bitterness and colonic neoplasms
Association between 6-n-propylthiouracil (PROP) bitterness and colonic neoplasms
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DOI：
10.1007/s10620-005-2462-7
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发表时间：
2005-03-01
影响因子：
3.1
通讯作者：
Duffy, VB
中科院分区：
文献类型：
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作者：
Basson, MD;Bartoshuk, LM;Duffy, VB
蔬菜摄入不足似乎会增加结肠癌的风险。由于口味的遗传变异影响蔬菜偏好，我们在 251 名接受过下段内窥镜检查的男性中测试了 6-正丙基硫氧嘧啶 (PROP) 的苦味（一种味觉遗传的衡量标准）与结肠息肉的数量（一项结肠癌风险的衡量标准）之间的关联。患者使用通用标记量表来评价通过滤纸递送的 1.6 mg PROP 的苦味。其中 86 名患者报告每周蔬菜摄入量，不包括沙拉或土豆。 PROP 苦味与息肉数量显着相关，这种影响与年龄相关的息肉数量增加无关。 PROP 与息肉的关系在 66 岁以上的男性中最为明显，患有息肉的老年男性最有可能超重或肥胖。在报告蔬菜摄入量的子集中，尝过 PROP 更苦的男性消耗的蔬菜较少。这些初步研究结果表明，味觉遗传学可能通过摄入蔬菜来影响结肠癌风险。
Inadequate vegetable intake appears to increase colon cancer risk. Since genetic variation in taste influences vegetable preference, we tested associations between bitterness of 6-n-propylthiouracil (PROP), a measure of taste genetics, and number of colonic polyps, a measure of colon cancer risk, in 251 men who underwent screening lower endoscopy. Patients used the general Labeled Magnitude Scale to rate bitterness of 1.6 mg PROP delivered via filter paper. A subset of 86 patients reported weekly vegetable intakes, excluding salad or potatoes. PROP bitterness correlated significantly with polyp number, an effect separate from age-associated increases in polyp number. The PROP-polyp relationship was strongest in men over 66 years, and older men with polyps were most likely to be overweight or obese. In the subset reporting vegetable intake, men who tasted PROP as more bitter consumed fewer vegetables. These preliminary findings suggest that taste genetics may influence colon cancer risk, possibly through intake of vegetables.