Three-dimensional analysis of water dynamics in human skin by stimulated Raman scattering imaging
Three-dimensional analysis of water dynamics in human skin by stimulated Raman scattering imaging
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DOI：
10.1117/12.2647651
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发表时间：
2023-03
期刊：
影响因子：
4.5
通讯作者：
T. Mizuguchi;C. T. Knight;M. Goto;Masato Ninomiya;M. Egawa;Y. Ozeki
中科院分区：
文献类型：
--
作者：
T. Mizuguchi;C. T. Knight;M. Goto;Masato Ninomiya;M. Egawa;Y. Ozeki
角质层（SC）是皮肤的最外层，在提供针对干燥环境的屏障方面起着至关重要的作用。为了了解皮肤的屏障功能和整体状况，必须评估SC吸收和保持水分的能力。在这项研究中，我们使用受激拉曼散射（SRS）成像研究的三维SC结构和水的分布作为水被吸收到干燥的SC片。我们的研究结果表明，水的吸收和保留的过程是依赖于特定的样品，可以是空间异质性。这些结果证明了SRS成像在诊断皮肤状况中的潜力。
The stratum corneum (SC), the outermost layer of the skin, plays a vital role in providing a barrier against dry environments. In order to understand the barrier function and overall condition of the skin, it is essential to assess the ability of the SC to absorb and retain water. In this study, we used stimulated Raman scattering (SRS) imaging to investigate the threedimensional SC structure and water distribution as water was absorbed into dried SC sheets. Our findings indicate that the process of water absorption and retention is dependent on the specific sample and can be spatially heterogeneous. These results demonstrate the potential of SRS imaging in diagnosing skin conditions.