Rapid automatic creation of monodisperse emulsion droplets by microfluidic device with degassed PDMS slab as a detachable suction actuator
Rapid automatic creation of monodisperse emulsion droplets by microfluidic device with degassed PDMS slab as a detachable suction actuator
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DOI：
10.1002/elps.201700247
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发表时间：
2018-02
期刊：
影响因子：
2.9
通讯作者：
Yuki Murata;Yuta Nakashoji;M. Kondo;Y. Tanaka;M. Hashimoto
中科院分区：
文献类型：
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作者：
Yuki Murata;Yuta Nakashoji;M. Kondo;Y. Tanaka;M. Hashimoto
我们之前开发了一种技术，该技术能够使用抽空的PDMS微流体装置自动创建单分散油包水液滴。虽然该装置在很长一段时间内产生液滴，但生产速度很慢（每秒约10滴）。在本研究中，我们的目标是通过重塑我们的器械配置，使用与我们先前工作中描述的相同的液体泵送原理来提高该速率。为了实现这一目标，我们开发了一种新的装置，其在空气捕获空隙空间（178 cm-1）内具有比我们早期装置（5.0 cm-1）大得多的PDMS表面积与体积比。这种设计方法是基于这样的想法，即较大的PDMS表面积与体积比可能在空隙空间内产生更高的真空，从而有助于更快的液体流动和增加的液滴产生速率。新设备由五层组成，具有脱气的PDMS板作为可拆卸的液体抽吸致动器，其堆叠在较低的微流体层上。在该装置中，液滴产生的速率在液滴形成的时间过程中增加，并达到约100%。在完全消耗负载水溶液（20 μL）之前，每秒470滴。
We previously developed a technique that enabled automatic creation of monodisperse water‐in‐oil droplets with the use of an air‐evacuated PDMS microfluidic device. Although the device generated droplets over a long‐time period, the production rate was slow (∼10 droplets per second). In the current study, we aimed to improve this rate, using the same fluid pumping principle described in our previous work, by remodeling our device configuration. To achieve this aim, we developed a new device with a much larger PDMS surface area‐to‐volume ratio within the air‐trapping void space (178 cm–1), than that of our earlier device (5.0 cm–1). This design approach was based on the idea that a larger PDMS surface area‐to‐volume ratio was likely to create a higher vacuum inside the void space, thereby contributing to faster liquid flow and an increased droplet generation rate. The new device consisting of five layers featuring a degassed PDMS slab as a detachable liquid‐suction actuator, which was stacked on a lower microfluidic layer. In this device, the rate of droplet production increased during the time‐course droplet formation and reached ca. 470 droplets per second immediately before completely consuming the loaded aqueous solution (20 μL).