DIURNAL-VARIATIONS IN THYROTROPIN, PROLACTIN AND CORTISOL DURING HUMAN-PREGNANCY
DIURNAL-VARIATIONS IN THYROTROPIN, PROLACTIN AND CORTISOL DURING HUMAN-PREGNANCY
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DOI：
10.1159/000293623
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发表时间：
1989-01-01
影响因子：
2.1
通讯作者：
VONSCHOULTZ, B
中科院分区：
文献类型：
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作者：
ERIKSSON, L;EDEN, S;VONSCHOULTZ, B
在4名妊娠晚期（妊娠34-38周）、2名妊娠早期（妊娠11周和17周）和2名非妊娠妇女中测量了血清促甲状腺素（TSH）、催乳素（PRL）和皮质醇浓度的日变化。血液样本通过非血栓性导管获得，使用便携式泵以每隔30分钟更换受体管的方式连续取血。血清TSH浓度在孕妇和非孕妇中均表现出昼夜变化，在午夜前后达到最大值。孕妇血清PRL浓度升高，但浓度有明显的变化，表明该激素是间歇性分泌的。孕妇的血清皮质醇浓度升高，但典型的昼夜模式持续存在，在午夜前后达到最低点，在清晨明显升高。结果表明，在人类怀孕期间，TSH和皮质醇的分泌也有昼夜变化，PRL的分泌也有间歇性的变化。
Diurnal variations in serum concentrations of thyrotropin (TSH), prolactin (PRL) and cortisol were measured in 4 women during late stages of pregnancy (gestational weeks 34-38), in 2 women at an early stage of pregnancy (gestational weeks 11 and 17) and in 2 nonpregnant women. Blood samples were obtained through a nonthrombogenic catheter using continuous withdrawal of blood by means of a portable pump changing the recipient tube at 30-min intervals. Serum TSH concentrations showed a diurnal variation in both pregnant and nonpregnant women with maximal values around midnight. Serum PRL concentrations were elevated in pregnant women but the concentrations showed marked variations indicating episodic secretion of the hormone. Serum cortisol concentrations increased in pregnant women, but the typical diurnal pattern persisted with nadir levels around midnight and marked elevations during the early morning hours. The results sugest that also during human pregnancy there is a diurnal variation in TSH and cortisol secretion, as well as an episodic secretion of PRL.