Prevalence and Clinical Correlates of Sarcopenia in Community-Dwelling Older People: Application of the EWGSOP Definition and Diagnostic Algorithm
Prevalence and Clinical Correlates of Sarcopenia in Community-Dwelling Older People: Application of the EWGSOP Definition and Diagnostic Algorithm
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DOI：
10.1093/gerona/glt149
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发表时间：
2014-04-01
影响因子：
5.1
通讯作者：
Ferrucci, Luigi
中科院分区：
文献类型：
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作者：
Volpato, Stefano;Bianchi, Lara;Ferrucci, Luigi
背景。肌肉损伤是老年人的常见病症，也是导致残疾和死亡的重要危险因素。本研究的目的是应用欧洲老年人肌肉减少症工作组的标准来估计意大利社区老年人样本中肌肉减少症的患病率并调查其临床相关性。方法。对参加 InCHIANTI 研究的 730 名参与者（74% 年龄在 65 岁及以上）进行横断面分析。肌肉减少症是根据欧洲老年人肌肉减少症工作组的标准，使用生物阻抗分析进行肌肉质量评估来定义的。使用逻辑回归分析来确定与肌肉减少症独立相关的因素。结果。欧洲老年人肌肉减少症工作组定义的肌肉减少症标准随着年龄的增长而急剧增加 (p < .001)，80 岁或以上的 31.6% 的女性和 17.4% 的男性受到这种情况的影响。高等教育（比值比：0.85；95% CI：0.74-0.98）、较低的胰岛素样生长因子 I（最低与最高三分位数，比值比：3.89；95% CI：1.03-14.1）和低生物利用度睾酮（比值比：2.67；95% CI：1.31-5.44）独立相关有可能是肌肉减少症。营养摄入、体力活动和合并症水平与肌肉减少症无关。结论。欧洲老年人肌肉减少症工作组确定的肌肉减少症标准是意大利八旬老人中相对常见的病症，其患病率随着年龄的增长而增加。本研究中确定的肌肉减少症的相关性可能会提出预防和治疗肌肉减少症的新方法。
Background. Muscle impairment is a common condition in older people and a powerful risk factor for disability and mortality. The aim of this study was to apply the European Working Group on Sarcopenia in Older People criteria to estimate the prevalence and investigate the clinical correlates of sarcopenia, in a sample of Italian community-dwelling older people.Methods. Cross-sectional analysis of 730 participants (74% aged 65 years and older) enrolled in the InCHIANTI study. Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People criteria using bioimpedance analysis for muscle mass assessment. Logistic regression analysis was used to identify the factors independently associated with sarcopenia.Results. Sarcopenia defined by the European Working Group on Sarcopenia in Older People criteria increased steeply with age (p < .001), with 31.6% of women and 17.4% of men aged 80 years or older being affected by this condition. Higher education (odds ratio: 0.85; 95% CI: 0.74-0.98), lower insulin-like growth factor I (lowest vs highest tertile, odds ratio: 3.89; 95% CI: 1.03-14.1), and low bioavailable testosterone (odds ratio: 2.67; 95% CI: 1.31-5.44) were independently associated with the likelihood of being sarcopenic. Nutritional intake, physical activity, and level of comorbidity were not associated with sarcopenia.Conclusions. Sarcopenia identified by the European Working Group on Sarcopenia in Older People criteria is a relatively common condition in Italian octogenarians, and its prevalence increases with aging. Correlates of sarcopenia identified in this study might suggest new approaches for prevention and treatment of sarcopenia.